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3ryt
From Proteopedia
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==The Plexin A1 intracellular region in complex with Rac1== | ==The Plexin A1 intracellular region in complex with Rac1== | ||
| - | <StructureSection load='3ryt' size='340' side='right' caption='[[3ryt]], [[Resolution|resolution]] 3.58Å' scene=''> | + | <StructureSection load='3ryt' size='340' side='right'caption='[[3ryt]], [[Resolution|resolution]] 3.58Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3ryt]] is a 3 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3ryt]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RYT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RYT FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.582Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ryt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ryt OCA], [https://pdbe.org/3ryt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ryt RCSB], [https://www.ebi.ac.uk/pdbsum/3ryt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ryt ProSAT]</span></td></tr> |
</table> | </table> | ||
| - | + | == Function == | |
| - | = | + | [https://www.uniprot.org/uniprot/PLXA1_MOUSE PLXA1_MOUSE] Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.<ref>PMID:10520994</ref> <ref>PMID:10781943</ref> |
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| - | </ | + | |
==See Also== | ==See Also== | ||
| - | *[[Plexin|Plexin]] | + | *[[Plexin 3D structures|Plexin 3D structures]] |
| + | *[[Rac 3D structures|Rac 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: He | + | [[Category: He H]] |
| - | [[Category: Zhang | + | [[Category: Zhang X]] |
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Current revision
The Plexin A1 intracellular region in complex with Rac1
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