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3s8o

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[[Image:3s8o.png|left|200px]]
 
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{{STRUCTURE_3s8o| PDB=3s8o | SCENE= }}
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==Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide==
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<StructureSection load='3s8o' size='340' side='right'caption='[[3s8o]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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===Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3s8o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S8O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S8O FirstGlance]. <br>
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{{ABSTRACT_PUBMED_22007755}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=02K:1-AMINOCYCLOHEXANECARBOXYLIC+ACID'>02K</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s8o OCA], [https://pdbe.org/3s8o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s8o RCSB], [https://www.ebi.ac.uk/pdbsum/3s8o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s8o ProSAT]</span></td></tr>
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[[3s8o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S8O OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GRB2_HUMAN GRB2_HUMAN] Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref> Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref>
==See Also==
==See Also==
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*[[Growth factor receptor-bound protein 2|Growth factor receptor-bound protein 2]]
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*[[Growth factor receptor-bound proteins 3D structures|Growth factor receptor-bound proteins 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:022007755</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Clements, J H.]]
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[[Category: Large Structures]]
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[[Category: Stephen, F M.]]
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[[Category: Clements JH]]
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[[Category: Grb2 sh2 domain]]
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[[Category: Stephen FM]]
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[[Category: Phosphotyrosine-containing tripeptide]]
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[[Category: Signaling protein-antagonist complex]]
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Current revision

Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide

PDB ID 3s8o

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