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3s9i

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[[Image:3s9i.jpg|left|200px]]
 
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{{STRUCTURE_3s9i| PDB=3s9i | SCENE= }}
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==Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 2-4-dioxo-4-phenylbutanoic acid inhibitor==
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<StructureSection load='3s9i' size='340' side='right'caption='[[3s9i]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3s9i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S9I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S9I FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=XI7:2-4-DIOXO-4-PHENYLBUTANOIC+ACID'>XI7</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s9i OCA], [https://pdbe.org/3s9i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s9i RCSB], [https://www.ebi.ac.uk/pdbsum/3s9i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s9i ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MASZ_MYCTU MASZ_MYCTU] Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA (By similarity).[HAMAP-Rule:MF_00641]
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===Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 2-4-dioxo-4-phenylbutanoic acid inhibitor===
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==See Also==
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*[[Malate synthase 3D structures|Malate synthase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[3s9i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S9I OCA].
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[[Category: Large Structures]]
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[[Category: Malate synthase]]
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[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Krieger, I V.]]
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[[Category: Krieger IV]]
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[[Category: Sacchettini, J C.]]
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[[Category: Sacchettini JC]]
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[[Category: Sun, Q.]]
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[[Category: Sun Q]]
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[[Category: XMTB, Mycobacterium Tuberculosis Structural Proteomics Project.]]
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[[Category: Inhibitor complex]]
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[[Category: Malate synthase]]
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[[Category: Mycobacterium tuberculosis structural proteomics project]]
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[[Category: Structural genomic]]
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[[Category: Transferase-transferase inhibitor complex]]
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[[Category: Xmtb]]
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Current revision

Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 2-4-dioxo-4-phenylbutanoic acid inhibitor

PDB ID 3s9i

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