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3skm
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| - | [[Image:3skm.png|left|200px]] | ||
| - | + | ==Crystal structure of the HLA-B8FLRGRAYVL, mutant G8V of the FLR peptide== | |
| - | + | <StructureSection load='3skm' size='340' side='right'caption='[[3skm]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3skm]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_4 Human gammaherpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SKM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SKM FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3skm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3skm OCA], [https://pdbe.org/3skm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3skm RCSB], [https://www.ebi.ac.uk/pdbsum/3skm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3skm ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[3skm]] is a 3 chain structure with sequence from [ | + | == Function == |
| + | [https://www.uniprot.org/uniprot/EBNA3_EBVG EBNA3_EBVG] Plays an essential role for activation and immortalization of human B-cells. Represses transcription of viral promoters TP1 and Cp through interaction with host RBPJ, and inhibits EBNA2-mediated activation of these promoters. Since Cp is the promoter for all EBNA mRNAs, EBNA3A probably contributes to a negative autoregulatory control loop (By similarity). | ||
==See Also== | ==See Also== | ||
| - | *[[Beta-2 microglobulin|Beta-2 microglobulin]] | + | *[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]] |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Human gammaherpesvirus 4]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Gras | + | [[Category: Burrows SR]] |
| - | [[Category: Hanim | + | [[Category: Gras S]] |
| - | [[Category: Kjer-Nielsen | + | [[Category: Hanim H]] |
| - | [[Category: Mccluskey | + | [[Category: Kjer-Nielsen L]] |
| - | [[Category: Purcell | + | [[Category: Mccluskey J]] |
| - | [[Category: Rossjohn | + | [[Category: Purcell AW]] |
| - | [[Category: Wilmann | + | [[Category: Rossjohn J]] |
| - | [[Category: | + | [[Category: Wilmann PG]] |
| - | [[Category: | + | [[Category: Yu Chih L]] |
| - | + | [[Category: Zhenjun C]] | |
Current revision
Crystal structure of the HLA-B8FLRGRAYVL, mutant G8V of the FLR peptide
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