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3smj

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[[Image:3smj.png|left|200px]]
 
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{{STRUCTURE_3smj| PDB=3smj | SCENE= }}
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==Human poly(ADP-ribose) polymerase 14 (Parp14/Artd8) - catalytic domain in complex with a pyrimidine-like inhibitor==
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<StructureSection load='3smj' size='340' side='right'caption='[[3smj]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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===Human poly(ADP-ribose) polymerase 14 (Parp14/Artd8) - catalytic domain in complex with a pyrimidine-like inhibitor===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3smj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SMJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SMJ FirstGlance]. <br>
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{{ABSTRACT_PUBMED_22343925}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FDR:2-METHYL-3,5,6,7-TETRAHYDRO-4H-CYCLOPENTA[4,5]THIENO[2,3-D]PYRIMIDIN-4-ONE'>FDR</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3smj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3smj OCA], [https://pdbe.org/3smj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3smj RCSB], [https://www.ebi.ac.uk/pdbsum/3smj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3smj ProSAT]</span></td></tr>
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[[3smj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SMJ OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PAR14_HUMAN PAR14_HUMAN] Enhances STAT6-dependent transcription (By similarity). Has ADP-ribosyltransferase activity.
==See Also==
==See Also==
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*[[Poly (ADP-ribose) polymerase|Poly (ADP-ribose) polymerase]]
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*[[Poly(ADP-ribose) polymerase 3D structures|Poly(ADP-ribose) polymerase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:022343925</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Berglund, H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C.]]
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[[Category: Berglund H]]
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[[Category: Edwards, A M.]]
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[[Category: Bountra C]]
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[[Category: Ekblad, T.]]
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[[Category: Edwards AM]]
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[[Category: Graslund, S.]]
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[[Category: Ekblad T]]
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[[Category: Karlberg, T.]]
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[[Category: Graslund S]]
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[[Category: Kouznetsova, E.]]
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[[Category: Karlberg T]]
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[[Category: Moche, M.]]
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[[Category: Kouznetsova E]]
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[[Category: Nordlund, P.]]
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[[Category: Moche M]]
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[[Category: Nyman, T.]]
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[[Category: Nordlund P]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Nyman T]]
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[[Category: Schuler, H.]]
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[[Category: Schuler H]]
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[[Category: Thorsell, A G.]]
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[[Category: Thorsell AG]]
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[[Category: Tresaugues, L.]]
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[[Category: Tresaugues L]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: Adp-ribosylation]]
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[[Category: Diphtheria toxin like fold]]
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[[Category: Nad+]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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[[Category: Transferase]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Human poly(ADP-ribose) polymerase 14 (Parp14/Artd8) - catalytic domain in complex with a pyrimidine-like inhibitor

PDB ID 3smj

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