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3so3
From Proteopedia
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| - | {{STRUCTURE_3so3| PDB=3so3 | SCENE= }} | ||
| - | ===Structures of Fab-Protease Complexes Reveal a Highly Specific Non-Canonical Mechanism of Inhibition.=== | ||
| - | {{ABSTRACT_PUBMED_22154938}} | ||
| - | == | + | ==Structures of Fab-Protease Complexes Reveal a Highly Specific Non-Canonical Mechanism of Inhibition.== |
| - | [[http://www.uniprot.org/uniprot/ST14_HUMAN ST14_HUMAN | + | <StructureSection load='3so3' size='340' side='right'caption='[[3so3]], [[Resolution|resolution]] 2.10Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3so3]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SO3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SO3 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FRU:FRUCTOSE'>FRU</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PRD_900003:sucrose'>PRD_900003</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3so3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3so3 OCA], [https://pdbe.org/3so3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3so3 RCSB], [https://www.ebi.ac.uk/pdbsum/3so3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3so3 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/ST14_HUMAN ST14_HUMAN] Defects in ST14 are a cause of ichthyosis autosomal recessive with hypotrichosis (ARIH) [MIM:[https://omim.org/entry/610765 610765]. ARIH is a skin disorder characterized by congenital ichthyosis associated with the presence of less than the normal amount of hair.<ref>PMID:17273967</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ST14_HUMAN ST14_HUMAN] Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Matriptase 3D structures|Matriptase 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Baharuddin | + | [[Category: Baharuddin A]] |
| - | [[Category: Craik | + | [[Category: Craik CS]] |
| - | [[Category: Egea | + | [[Category: Egea PF]] |
| - | [[Category: Farady | + | [[Category: Farady CJ]] |
| - | [[Category: Goetz | + | [[Category: Goetz DH]] |
| - | [[Category: Schneider | + | [[Category: Schneider EL]] |
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Current revision
Structures of Fab-Protease Complexes Reveal a Highly Specific Non-Canonical Mechanism of Inhibition.
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