This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3soc

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:03, 14 March 2024) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3soc.png|left|200px]]
 
-
<!--
+
==Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with a quinazolin==
-
The line below this paragraph, containing "STRUCTURE_3soc", creates the "Structure Box" on the page.
+
<StructureSection load='3soc' size='340' side='right'caption='[[3soc]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3soc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SOC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SOC FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GVD:[4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]QUINAZOLIN-2-YL}IMINO)CYCLOHEXA-2,5-DIEN-1-YL]ACETONITRILE'>GVD</scene></td></tr>
-
{{STRUCTURE_3soc| PDB=3soc | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3soc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3soc OCA], [https://pdbe.org/3soc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3soc RCSB], [https://www.ebi.ac.uk/pdbsum/3soc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3soc ProSAT]</span></td></tr>
-
 
+
</table>
-
===Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with a quinazolin===
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/AVR2A_HUMAN AVR2A_HUMAN] On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.
-
 
+
__TOC__
-
==About this Structure==
+
</StructureSection>
-
[[3soc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SOC OCA].
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Receptor protein serine/threonine kinase]]
+
[[Category: Large Structures]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Bountra, C.]]
+
[[Category: Bountra C]]
-
[[Category: Bullock, A.]]
+
[[Category: Bullock A]]
-
[[Category: Chaikuad, A.]]
+
[[Category: Chaikuad A]]
-
[[Category: Cooper, C D.O.]]
+
[[Category: Cooper CDO]]
-
[[Category: Delft, F von.]]
+
[[Category: Edwards AM]]
-
[[Category: Edwards, A M.]]
+
[[Category: Mahajan P]]
-
[[Category: Mahajan, P.]]
+
[[Category: Muniz JRC]]
-
[[Category: Muniz, J R.C.]]
+
[[Category: Sanvitale C]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Vollmar M]]
-
[[Category: Sanvitale, C.]]
+
[[Category: Weigelt J]]
-
[[Category: Vollmar, M.]]
+
[[Category: Williams E]]
-
[[Category: Weigelt, J.]]
+
[[Category: Yue WW]]
-
[[Category: Williams, E.]]
+
[[Category: Von Delft F]]
-
[[Category: Yue, W W.]]
+
-
[[Category: Protein kinase]]
+
-
[[Category: Sgc]]
+
-
[[Category: Structural genomics consortium]]
+
-
[[Category: Transferase]]
+

Current revision

Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with a quinazolin

PDB ID 3soc

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3soc"
Personal tools