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3sph
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3sph is ON HOLD Authors: Hansen, S.B., Tao, X., MacKinnon, R. Description: Structural basis of PIP2 activation of the classical inward rectifier K+...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Inward rectifier potassium channel Kir2.2 I223L mutant in complex with PIP2== | |
| + | <StructureSection load='3sph' size='340' side='right'caption='[[3sph]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3sph]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SPH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SPH FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.003Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PIO:[(2R)-2-OCTANOYLOXY-3-[OXIDANYL-[(1R,2R,3S,4R,5R,6S)-2,3,6-TRIS(OXIDANYL)-4,5-DIPHOSPHONOOXY-CYCLOHEXYL]OXY-PHOSPHORYL]OXY-PROPYL]+OCTANOATE'>PIO</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sph OCA], [https://pdbe.org/3sph PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sph RCSB], [https://www.ebi.ac.uk/pdbsum/3sph PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sph ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/KCJ12_CHICK KCJ12_CHICK] Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. The inward rectification is probably due to the blockage of outward current by cytoplasmic polyamines and/or magnesium ions.<ref>PMID:20019282</ref> <ref>PMID:21874019</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Potassium channel 3D structures|Potassium channel 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Gallus gallus]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Hansen SB]] | ||
| + | [[Category: MacKinnon R]] | ||
| + | [[Category: Tao X]] | ||
Current revision
Inward rectifier potassium channel Kir2.2 I223L mutant in complex with PIP2
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