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3sr2
From Proteopedia
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| - | [[Image:3sr2.png|left|200px]] | ||
| - | + | ==Crystal Structure of Human XLF-XRCC4 Complex== | |
| - | + | <StructureSection load='3sr2' size='340' side='right'caption='[[3sr2]], [[Resolution|resolution]] 3.97Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3sr2]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SR2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SR2 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.9708Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sr2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sr2 OCA], [https://pdbe.org/3sr2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sr2 RCSB], [https://www.ebi.ac.uk/pdbsum/3sr2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sr2 ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/XRCC4_HUMAN XRCC4_HUMAN] Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.<ref>PMID:8548796</ref> <ref>PMID:10854421</ref> <ref>PMID:10757784</ref> <ref>PMID:16412978</ref> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | == | + | __TOC__ |
| - | [[3sr2]] is a 8 chain structure with sequence from [ | + | </StructureSection> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Classen S]] |
| - | [[Category: | + | [[Category: Hammel M]] |
| - | [[Category: | + | [[Category: Tainer JA]] |
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Current revision
Crystal Structure of Human XLF-XRCC4 Complex
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