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3sr4

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[[Image:3sr4.jpg|left|200px]]
 
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==Crystal Structure of Human DOT1L in Complex with a Selective Inhibitor==
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The line below this paragraph, containing "STRUCTURE_3sr4", creates the "Structure Box" on the page.
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<StructureSection load='3sr4' size='340' side='right'caption='[[3sr4]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3sr4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SR4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SR4 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TT8:(2S)-2-AZANYL-4-[[(2S,3S,4R,5R)-5-[6-(METHYLAMINO)PURIN-9-YL]-3,4-BIS(OXIDANYL)OXOLAN-2-YL]METHYLSULFANYL]BUTANOIC+ACID'>TT8</scene></td></tr>
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{{STRUCTURE_3sr4| PDB=3sr4 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sr4 OCA], [https://pdbe.org/3sr4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sr4 RCSB], [https://www.ebi.ac.uk/pdbsum/3sr4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sr4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DOT1L_HUMAN DOT1L_HUMAN] Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.
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===Crystal Structure of Human DOT1L in Complex with a Selective Inhibitor===
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==See Also==
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*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
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__TOC__
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 21936531 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21936531}}
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==About this Structure==
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[[3sr4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SR4 OCA].
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==Reference==
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<ref group="xtra">PMID:021936531</ref><references group="xtra"/>
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[[Category: Histone-lysine N-methyltransferase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chen, P.]]
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[[Category: Large Structures]]
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[[Category: Diao, J.]]
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[[Category: Chen P]]
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[[Category: Prasad, B V.V.]]
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[[Category: Diao J]]
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[[Category: Song, Y.]]
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[[Category: Prasad BVV]]
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[[Category: Yao, Y.]]
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[[Category: Song Y]]
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[[Category: Hdot1]]
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[[Category: Yao Y]]
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[[Category: Histone lysine methyltransferase]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Crystal Structure of Human DOT1L in Complex with a Selective Inhibitor

PDB ID 3sr4

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