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3srb
From Proteopedia
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| - | [[Image:3srb.png|left|200px]] | ||
| - | + | ==Structure of Pseudomonas aeruginosa PvdQ bound to SMER28== | |
| - | + | <StructureSection load='3srb' size='340' side='right'caption='[[3srb]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3srb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SRB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SRB FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=28S:6-BROMO-N-(PROP-2-EN-1-YL)QUINAZOLIN-4-AMINE'>28S</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3srb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3srb OCA], [https://pdbe.org/3srb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3srb RCSB], [https://www.ebi.ac.uk/pdbsum/3srb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3srb ProSAT]</span></td></tr> |
| - | [[3srb]] is a 2 chain structure with sequence from [ | + | </table> |
| - | + | == Function == | |
| - | == | + | [https://www.uniprot.org/uniprot/PVDQ_PSEAE PVDQ_PSEAE] Catalyzes the deacylation of acyl-homoserine lactone (AHL or acyl-HSL), releasing homoserine lactone (HSL) and the corresponding fatty acid. Possesses a specificity for the degradation of long-chain acyl-HSLs (side chains of 11 to 14 carbons in length). Degrades 3-oxo-C12-HSL, one of the two main AHL signal molecules of P.aeruginosa, and thereby functions as a quorum quencher, inhibiting the las quorum-sensing system. Therefore, may enable P.aeruginosa to modulate its own quorum-sensing-dependent pathogenic potential. Also appears to be required for pyoverdin biosynthesis.<ref>PMID:16495538</ref> <ref>PMID:14532048</ref> <ref>PMID:12686626</ref> |
| - | < | + | == References == |
| - | [[ | + | <references/> |
| - | [ | + | __TOC__ |
| - | [ | + | </StructureSection> |
| - | [ | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Pseudomonas aeruginosa PAO1]] |
| - | [[Category: | + | [[Category: Drake EJ]] |
| - | [[Category: | + | [[Category: Gulick AM]] |
| - | [[Category: | + | |
Current revision
Structure of Pseudomonas aeruginosa PvdQ bound to SMER28
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