1r2h

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[[Image:1r2h.gif|left|200px]]
[[Image:1r2h.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1r2h |SIZE=350|CAPTION= <scene name='initialview01'>1r2h</scene>, resolution 2.20&Aring;
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The line below this paragraph, containing "STRUCTURE_1r2h", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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|GENE= BCL-XL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_1r2h| PDB=1r2h | SCENE= }}
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|RELATEDENTRY=[[1maz|1MAZ]], [[1r2d|1R2D]], [[1r2e|1R2E]], [[1r2g|1R2G]], [[1r2i|1R2I]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r2h OCA], [http://www.ebi.ac.uk/pdbsum/1r2h PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1r2h RCSB]</span>
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'''Human Bcl-XL containing an Ala to Leu mutation at position 142'''
'''Human Bcl-XL containing an Ala to Leu mutation at position 142'''
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[[Category: Neill, J W.O.]]
[[Category: Neill, J W.O.]]
[[Category: Zhang, K Y.]]
[[Category: Zhang, K Y.]]
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[[Category: alpha-helical]]
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[[Category: Alpha-helical]]
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[[Category: apoptosis]]
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[[Category: Apoptosis]]
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[[Category: monomeric]]
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[[Category: Monomeric]]
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[[Category: mutation]]
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[[Category: Mutation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:59:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:22:19 2008''
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Revision as of 03:59, 3 May 2008

Image:1r2h.gif

Template:STRUCTURE 1r2h

Human Bcl-XL containing an Ala to Leu mutation at position 142


Overview

Cells expressing high levels of the BCL-X(L) anti-apoptotic protein are preferentially killed by the mitochondrial inhibitor antimycin A (AA). Computational modeling predicts a binding site for AA in the extended hydrophobic groove on BCL-X(L), previously identified as an interface for dimerization to BAX and related proapoptotic proteins. Here, we identify BCL-X(L) hydrophobic groove mutants with normal cellular anti-apoptotic function but suppressed sensitivity to AA. The LD(50) of AA for cells expressing BCL-X(L) mutants directly correlates with the measured in vitro dissociation constants for AA binding. These results indicate that BCL-X(L) is a principal target mediating AA cytotoxicity.

About this Structure

1R2H is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Bcl-XL mutations suppress cellular sensitivity to antimycin A., Manion MK, O'Neill JW, Giedt CD, Kim KM, Zhang KY, Hockenbery DM, J Biol Chem. 2004 Jan 16;279(3):2159-65. Epub 2003 Oct 8. PMID:14534311 Page seeded by OCA on Sat May 3 06:59:47 2008

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