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3swy

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[[Image:3swy.jpg|left|200px]]
 
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==CNGA3 626-672 containing CLZ domain==
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The line below this paragraph, containing "STRUCTURE_3swy", creates the "Structure Box" on the page.
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<StructureSection load='3swy' size='340' side='right'caption='[[3swy]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3swy]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SWY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SWY FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3swy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3swy OCA], [https://pdbe.org/3swy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3swy RCSB], [https://www.ebi.ac.uk/pdbsum/3swy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3swy ProSAT]</span></td></tr>
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{{STRUCTURE_3swy| PDB=3swy | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CNGA3_HUMAN CNGA3_HUMAN] Achromatopsia;Cone rod dystrophy. The disease is caused by mutations affecting the gene represented in this entry. Defects in CNGA3 may be a cause of Leber congenital amaurosis (LCA), a severe dystrophy of the retina, typically becoming evident in the first years of life. Visual function is usually poor and often accompanied by nystagmus, sluggish or near-absent pupillary responses, photophobia, high hyperopia and keratoconus.
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== Function ==
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[https://www.uniprot.org/uniprot/CNGA3_HUMAN CNGA3_HUMAN] Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones.<ref>PMID:10888875</ref>
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===CNGA3 626-672 containing CLZ domain===
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==See Also==
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*[[Ion channels 3D structures|Ion channels 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21878911 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21878911}}
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==About this Structure==
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[[3swy]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SWY OCA].
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==Reference==
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<ref group="xtra">PMID:021878911</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Black, K D.]]
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[[Category: Large Structures]]
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[[Category: Camp, S S.]]
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[[Category: Black KD]]
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[[Category: Haitin, Y.]]
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[[Category: Camp SS]]
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[[Category: Shuart, N G.]]
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[[Category: Haitin Y]]
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[[Category: Zagotta, W N.]]
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[[Category: Shuart NG]]
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[[Category: Assembly domain]]
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[[Category: Zagotta WN]]
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[[Category: Coiled-coil]]
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[[Category: Transport protein]]
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Current revision

CNGA3 626-672 containing CLZ domain

PDB ID 3swy

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