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3syx
From Proteopedia
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==Crystal Structure of the WH1 domain from human sprouty-related, EVH1 domain-containing protein. Northeast Structural Genomics Consortium Target HR5538B.== | ==Crystal Structure of the WH1 domain from human sprouty-related, EVH1 domain-containing protein. Northeast Structural Genomics Consortium Target HR5538B.== | ||
| - | <StructureSection load='3syx' size='340' side='right' caption='[[3syx]], [[Resolution|resolution]] 2.45Å' scene=''> | + | <StructureSection load='3syx' size='340' side='right'caption='[[3syx]], [[Resolution|resolution]] 2.45Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3syx]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3syx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SYX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SYX FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.453Å</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YT3:YTTRIUM+(III)+ION'>YT3</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3syx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3syx OCA], [https://pdbe.org/3syx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3syx RCSB], [https://www.ebi.ac.uk/pdbsum/3syx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3syx ProSAT]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/SPRE1_HUMAN SPRE1_HUMAN] Legius syndrome. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SPRE1_HUMAN SPRE1_HUMAN] Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow (By similarity). | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Acton TB]] |
| - | [[Category: | + | [[Category: Ciccosanti C]] |
| - | [[Category: | + | [[Category: Everett JK]] |
| - | [[Category: | + | [[Category: Hunt JF]] |
| - | [[Category: | + | [[Category: Montelione GT]] |
| - | [[Category: Nair | + | [[Category: Nair R]] |
| - | [[Category: Rost | + | [[Category: Rost B]] |
| - | [[Category: Sahdev | + | [[Category: Sahdev S]] |
| - | [[Category: Seetharaman | + | [[Category: Seetharaman J]] |
| - | [[Category: Shastry | + | [[Category: Shastry R]] |
| - | [[Category: Su | + | [[Category: Su M]] |
| - | [[Category: Tong | + | [[Category: Tong L]] |
| - | [[Category: Vorobiev | + | [[Category: Vorobiev S]] |
| - | [[Category: Xiao | + | [[Category: Xiao R]] |
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Current revision
Crystal Structure of the WH1 domain from human sprouty-related, EVH1 domain-containing protein. Northeast Structural Genomics Consortium Target HR5538B.
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Categories: Homo sapiens | Large Structures | Acton TB | Ciccosanti C | Everett JK | Hunt JF | Montelione GT | Nair R | Rost B | Sahdev S | Seetharaman J | Shastry R | Su M | Tong L | Vorobiev S | Xiao R
