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3t42

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[[Image:3t42.jpg|left|200px]]
 
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==Human aldose reductase in complex with a nitrile-containing IDD inhibitor==
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The line below this paragraph, containing "STRUCTURE_3t42", creates the "Structure Box" on the page.
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<StructureSection load='3t42' size='340' side='right'caption='[[3t42]], [[Resolution|resolution]] 1.28&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3t42]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T42 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T42 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.28&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3T4:{5-CHLORO-2-[(4-CYANO-3-NITROBENZYL)CARBAMOYL]PHENOXY}ACETIC+ACID'>3T4</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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{{STRUCTURE_3t42| PDB=3t42 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t42 OCA], [https://pdbe.org/3t42 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t42 RCSB], [https://www.ebi.ac.uk/pdbsum/3t42 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t42 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
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===Human aldose reductase in complex with a nitrile-containing IDD inhibitor===
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==See Also==
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*[[Aldose reductase 3D structures|Aldose reductase 3D structures]]
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__TOC__
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 21859105 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21859105}}
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==About this Structure==
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[[3t42]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T42 OCA].
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==Reference==
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<ref group="xtra">PMID:021859105</ref><references group="xtra"/>
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[[Category: Aldehyde reductase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Boxer, S G.]]
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[[Category: Large Structures]]
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[[Category: Cohen, A E.]]
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[[Category: Boxer SG]]
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[[Category: Xu, L.]]
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[[Category: Cohen AE]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Xu L]]
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[[Category: Tim barrel]]
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Current revision

Human aldose reductase in complex with a nitrile-containing IDD inhibitor

PDB ID 3t42

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OCA

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