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3tby

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CRYSTAL STRUCTURE OF THE MURINE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX H-2DB IN COMPLEX WITH THE LCMV-DERIVED GP33 ALTERED PEPTIDE ligand (V3P, Y4F)

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 ==CRYSTAL STRUCTURE OF THE MURINE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX H-2DB IN COMPLEX WITH THE LCMV-DERIVED GP33 ALTERED PEPTIDE ligand (V3P, Y4F)==
-<StructureSection load='3tby' size='340' side='right' caption='[[3tby]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
+<StructureSection load='3tby' size='340' side='right'caption='[[3tby]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3tby]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TBY FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3tby]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Lymphocytic_choriomeningitis_virus_(strain_WE) Lymphocytic choriomeningitis virus (strain WE)] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TBY FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1s7u|1s7u]], [[1s7v|1s7v]], [[1s7w|1s7w]], [[1s7x|1s7x]], [[3qul|3qul]], [[3quk|3quk]], [[3tbs|3tbs]], [[3tbt|3tbt]], [[3tbv|3tbv]], [[3tbw|3tbw]], [[3tbx|3tbx]]</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">H2-D1, H2-DB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), B2m ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tby OCA], [https://pdbe.org/3tby PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tby RCSB], [https://www.ebi.ac.uk/pdbsum/3tby PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tby ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tby OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tby RCSB], [http://www.ebi.ac.uk/pdbsum/3tby PDBsum]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/GLYC_LYCVW GLYC_LYCVW]] The stable signal peptide (SSP) is cleaved and functions as a signal peptide. In addition, it is apparently retained as the third component of the GP complex. The SSP is required for efficient glycoprotein expression, post-translational maturation cleavage of GP1 and GP2, glycoprotein transport to the cell surface plasma membrane, formation of infectious virus particles, and acid pH-dependent glycoprotein-mediated cell fusion (By similarity).  Glycoprotein G1 mediates virus attachment to host receptor alpha-dystroglycan DAG1. This attachment induces virion internalization predominantly through clathrin- and caveolin-independent endocytosis (By similarity).  Glycoprotein G2 is a viral fusion protein. Membrane fusion is mediated by conformational changes induced upon acidification in the endosome (Potential). [[http://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
+[https://www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE] Involved in the presentation of foreign antigens to the immune system.
 ==See Also==
-*[[Beta-2 microglobulin|Beta-2 microglobulin]]
+*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
-*[[Major histocompatibility complex|Major histocompatibility complex]]
+*[[MHC 3D structures|MHC 3D structures]]
+*[[MHC I 3D structures|MHC I 3D structures]]
 __TOC__
 </StructureSection>
+[[Category: Large Structures]]
 [[Category: Mus musculus]]
-[[Category: Achour, A]]
+[[Category: Achour A]]
-[[Category: Allerbring, E B]]
+[[Category: Allerbring EB]]
-[[Category: Badia-Martinez, D]]
+[[Category: Badia-Martinez D]]
-[[Category: Duru, A D]]
+[[Category: Duru AD]]
-[[Category: Madhurantakam, C]]
+[[Category: Madhurantakam C]]
-[[Category: Mazumdar, P A]]
+[[Category: Mazumdar PA]]
-[[Category: Nygren, P]]
+[[Category: Nygren P]]
-[[Category: Sandalova, T]]
+[[Category: Sandalova T]]
-[[Category: Uchtenhagen, H]]
+[[Category: Uchtenhagen H]]
-[[Category: Agonism]]
-[[Category: Altered peptide ligand]]
-[[Category: Antagonism]]
-[[Category: Antigen presentation]]
-[[Category: Beta2-microglobulin]]
-[[Category: Cd8]]
-[[Category: Cell surface]]
-[[Category: Immune system]]
-[[Category: Immune system-agonist complex]]
-[[Category: Lcmv]]
-[[Category: Murine mhc]]
-[[Category: Receptor binding]]
-[[Category: T cell receptor]]
-[[Category: T cell recognition]]

3tby

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Current revision

CRYSTAL STRUCTURE OF THE MURINE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX H-2DB IN COMPLEX WITH THE LCMV-DERIVED GP33 ALTERED PEPTIDE ligand (V3P, Y4F)

Structural highlights

Function

See Also

Contents

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