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3tfs

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[[Image:3tfs.png|left|200px]]
 
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{{STRUCTURE_3tfs| PDB=3tfs | SCENE= }}
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==Ternary complex structure of DNA polymerase beta with a gapped DNA substrate and a, b dAMP(CFH)PP in the active site: Stereoselective binding of (S) isomer==
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<StructureSection load='3tfs' size='340' side='right'caption='[[3tfs]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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===Ternary complex structure of DNA polymerase beta with a gapped DNA substrate and a, b dAMP(CFH)PP in the active site: Stereoselective binding of (S) isomer===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3tfs]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TFS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TFS FirstGlance]. <br>
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{{ABSTRACT_PUBMED_22315190}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FHA:2-DEOXY-5-O-[(S)-{(S)-FLUORO[(S)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]METHYL}(HYDROXY)PHOSPHORYL]ADENOSINE'>FHA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tfs OCA], [https://pdbe.org/3tfs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tfs RCSB], [https://www.ebi.ac.uk/pdbsum/3tfs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tfs ProSAT]</span></td></tr>
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[[3tfs]] is a 4 chain structure of [[DNA polymerase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TFS OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DPOLB_HUMAN DPOLB_HUMAN] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<ref>PMID:9207062</ref> <ref>PMID:9572863</ref> <ref>PMID:11805079</ref> <ref>PMID:21362556</ref>
==See Also==
==See Also==
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*[[DNA polymerase|DNA polymerase]]
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*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:022315190</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Batra, V K.]]
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[[Category: Large Structures]]
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[[Category: Beard, W A.]]
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[[Category: Batra VK]]
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[[Category: Chamberlain, B T.]]
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[[Category: Beard WA]]
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[[Category: Goodman, M F.]]
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[[Category: Chamberlain BT]]
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[[Category: Kadina, A P.]]
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[[Category: Goodman MF]]
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[[Category: Kashemirov, B A.]]
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[[Category: Kadina AP]]
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[[Category: McKenna, C E.]]
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[[Category: Kashemirov BA]]
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[[Category: Shock, D D.]]
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[[Category: McKenna CE]]
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[[Category: Wilson, S H.]]
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[[Category: Shock DD]]
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[[Category: Dna polymerase]]
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[[Category: Wilson SH]]
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[[Category: Stereoselectivity]]
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[[Category: Transferase-dna complex]]
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Current revision

Ternary complex structure of DNA polymerase beta with a gapped DNA substrate and a, b dAMP(CFH)PP in the active site: Stereoselective binding of (S) isomer

PDB ID 3tfs

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