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3thi

From Proteopedia

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{{Seed}}
 
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[[Image:3thi.png|left|200px]]
 
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<!--
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==THIAMINASE I FROM BACILLUS THIAMINOLYTICUS==
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The line below this paragraph, containing "STRUCTURE_3thi", creates the "Structure Box" on the page.
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<StructureSection load='3thi' size='340' side='right'caption='[[3thi]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3thi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3THI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3THI FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3thi| PDB=3thi | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3thi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3thi OCA], [https://pdbe.org/3thi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3thi RCSB], [https://www.ebi.ac.uk/pdbsum/3thi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3thi ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/THI1_PANTH THI1_PANTH] Degrades thiamine by replacing its thiazole moiety with a wide range of nucleophiles.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/th/3thi_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3thi ConSurf].
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<div style="clear:both"></div>
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===THIAMINASE I FROM BACILLUS THIAMINOLYTICUS===
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==See Also==
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*[[Thiaminase|Thiaminase]]
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__TOC__
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<!--
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_9843405}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9843405 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9843405}}
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==About this Structure==
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3THI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3THI OCA].
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==Reference==
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Crystal structure of thiaminase-I from Bacillus thiaminolyticus at 2.0 A resolution., Campobasso N, Costello CA, Kinsland C, Begley TP, Ealick SE, Biochemistry. 1998 Nov 10;37(45):15981-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9843405 9843405]
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[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Thiamine pyridinylase]]
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[[Category: Begley TP]]
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[[Category: Begley, T P.]]
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[[Category: Campobasso N]]
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[[Category: Campobasso, N.]]
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[[Category: Ealick SE]]
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[[Category: Ealick, S E.]]
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[[Category: Thiamin degradation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:09:08 2008''
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Current revision

THIAMINASE I FROM BACILLUS THIAMINOLYTICUS

PDB ID 3thi

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