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3thm

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[[Image:3thm.jpg|left|200px]]
 
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==Crystal structure of Fas receptor extracellular domain in complex with Fab EP6b_B01==
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The line below this paragraph, containing "STRUCTURE_3thm", creates the "Structure Box" on the page.
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<StructureSection load='3thm' size='340' side='right'caption='[[3thm]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3thm]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3THM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3THM FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_3thm| PDB=3thm | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3thm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3thm OCA], [https://pdbe.org/3thm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3thm RCSB], [https://www.ebi.ac.uk/pdbsum/3thm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3thm ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/TNR6_HUMAN TNR6_HUMAN] Defects in FAS are the cause of autoimmune lymphoproliferative syndrome type 1A (ALPS1A) [MIM:[https://omim.org/entry/601859 601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly.<ref>PMID:17336828</ref> <ref>PMID:7540117</ref> <ref>PMID:8929361</ref> <ref>PMID:9028321</ref> <ref>PMID:9028957</ref> <ref>PMID:9322534</ref> <ref>PMID:9821419</ref> <ref>PMID:10090885</ref> <ref>PMID:10515860</ref> <ref>PMID:10340403</ref> <ref>PMID:9927496</ref> <ref>PMID:11418480</ref> <ref>PMID:20935634</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/TNR6_HUMAN TNR6_HUMAN] Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).<ref>PMID:7533181</ref> <ref>PMID:19118384</ref>
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===Crystal structure of Fas receptor extracellular domain in complex with Fab EP6b_B01===
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==See Also==
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*[[Tumor necrosis factor receptor 3D structures|Tumor necrosis factor receptor 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22261618 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22261618}}
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==About this Structure==
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[[3thm]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3THM OCA].
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==Reference==
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<ref group="xtra">PMID:022261618</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Briand, C.]]
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[[Category: Large Structures]]
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[[Category: Grutter, M G.]]
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[[Category: Briand C]]
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[[Category: Stirnimann, C.]]
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[[Category: Grutter MG]]
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[[Category: Zuger, S.]]
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[[Category: Stirnimann C]]
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[[Category: Agonistic antibody]]
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[[Category: Zuger S]]
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[[Category: Antibody-receptor complex]]
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[[Category: Cysteine-rich domain]]
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[[Category: Fab fragment]]
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[[Category: Fa]]
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[[Category: Immune system]]
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[[Category: Tumor necrosis factor receptor]]
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Current revision

Crystal structure of Fas receptor extracellular domain in complex with Fab EP6b_B01

PDB ID 3thm

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