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3thr

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[[Image:3thr.jpg|left|200px]]
 
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==Crystal structure of rat native liver Glycine N-methyltransferase complexed with 5-methyltetrahydrofolate monoglutamate==
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The line below this paragraph, containing "STRUCTURE_3thr", creates the "Structure Box" on the page.
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<StructureSection load='3thr' size='340' side='right'caption='[[3thr]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3thr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3THR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3THR FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=C2F:5-METHYL-5,6,7,8-TETRAHYDROFOLIC+ACID'>C2F</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene></td></tr>
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{{STRUCTURE_3thr| PDB=3thr | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3thr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3thr OCA], [https://pdbe.org/3thr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3thr RCSB], [https://www.ebi.ac.uk/pdbsum/3thr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3thr ProSAT]</span></td></tr>
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</table>
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===Crystal structure of rat native liver Glycine N-methyltransferase complexed with 5-methyltetrahydrofolate monoglutamate===
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== Function ==
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[https://www.uniprot.org/uniprot/GNMT_RAT GNMT_RAT] Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22037183 is the PubMed ID number.
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{{ABSTRACT_PUBMED_22037183}}
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==About this Structure==
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[[3thr]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3THR OCA].
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==Reference==
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<ref group="xtra">PMID:022037183</ref><references group="xtra"/>
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[[Category: Glycine N-methyltransferase]]
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Loukachevitch, L V.]]
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[[Category: Loukachevitch LV]]
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[[Category: Luka, Z.]]
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[[Category: Luka Z]]
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[[Category: Newcomer, M E.]]
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[[Category: Newcomer ME]]
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[[Category: Pakhomova, S.]]
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[[Category: Pakhomova S]]
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[[Category: Wagner, C.]]
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[[Category: Wagner C]]
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[[Category: Folate]]
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[[Category: Folate binding]]
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[[Category: Glycine n-methyltransferase]]
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[[Category: Gnmt]]
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[[Category: Liver cytosol]]
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[[Category: Methyltransferase]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Crystal structure of rat native liver Glycine N-methyltransferase complexed with 5-methyltetrahydrofolate monoglutamate

PDB ID 3thr

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