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3tpw

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Current revision (13:36, 14 March 2024) (edit) (undo)
 
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<StructureSection load='3tpw' size='340' side='right'caption='[[3tpw]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
<StructureSection load='3tpw' size='340' side='right'caption='[[3tpw]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3tpw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mpmv Mpmv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TPW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TPW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3tpw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mason-Pfizer_monkey_virus Mason-Pfizer monkey virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TPW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TPW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DUP:2-DEOXYURIDINE+5-ALPHA,BETA-IMIDO-TRIPHOSPHATE'>DUP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2d4n|2d4n]], [[2d4l|2d4l]], [[2d4m|2d4m]], [[3tp1|3tp1]], [[3tpn|3tpn]], [[3tps|3tps]], [[3tpy|3tpy]], [[3tq3|3tq3]], [[3tq4|3tq4]], [[3tq5|3tq5]], [[3trl|3trl]], [[3trn|3trn]], [[3ts6|3ts6]], [[3tsl|3tsl]], [[3tta|3tta]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DUP:2-DEOXYURIDINE+5-ALPHA,BETA-IMIDO-TRIPHOSPHATE'>DUP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gag-pro ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11855 MPMV])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tpw OCA], [https://pdbe.org/3tpw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tpw RCSB], [https://www.ebi.ac.uk/pdbsum/3tpw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tpw ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tpw OCA], [https://pdbe.org/3tpw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tpw RCSB], [https://www.ebi.ac.uk/pdbsum/3tpw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tpw ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PRO_MPMV PRO_MPMV] Matrix protein. Nucleocapsid protein p14: Nucleocapsid protein. Capsid protein. The aspartyl protease mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane. Cleavages take place as an ordered, step-wise cascade to yield mature proteins. This process is called maturation. Displays maximal activity during the budding process just prior to particle release from the cell.[PROSITE-ProRule:PRU00275]<ref>PMID:9636364</ref> The aspartyl protease mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane. Cleavages take place as an ordered, step-wise cascade to yield mature proteins. This process is called maturation. Displays maximal activity during the budding process just prior to particle release from the cell.[PROSITE-ProRule:PRU00275]<ref>PMID:9636364</ref> Enhances the activity of the reverse transcriptase. May be part of the mature RT.<ref>PMID:22171253</ref>
==See Also==
==See Also==
*[[DUTPase 3D structures|DUTPase 3D structures]]
*[[DUTPase 3D structures|DUTPase 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Mpmv]]
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[[Category: Mason-Pfizer monkey virus]]
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[[Category: DUTP diphosphatase]]
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[[Category: Barabas O]]
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[[Category: Barabas, O]]
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[[Category: Nemeth V]]
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[[Category: Nemeth, V]]
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[[Category: Vertessy BG]]
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[[Category: Vertessy, B G]]
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[[Category: Hydrolase]]
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[[Category: Jelly roll]]
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Current revision

CRYSTAL STRUCTURE OF M-PMV DUTPASE - DUPNPP complex revealing distorted ligand geometry (approach intermediate)

PDB ID 3tpw

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