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3tzi
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3tzi is ON HOLD Authors: Vecchio, A.J., Malkowski, M.G. Description: X-ray crystal structure of arachidonic acid bound in the cyclooxygenase channe...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==X-ray crystal structure of arachidonic acid bound in the cyclooxygenase channel of G533V murine COX-2== | |
| + | <StructureSection load='3tzi' size='340' side='right'caption='[[3tzi]], [[Resolution|resolution]] 2.15Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3tzi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TZI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TZI FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACD:ARACHIDONIC+ACID'>ACD</scene>, <scene name='pdbligand=AKR:ACRYLIC+ACID'>AKR</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=COH:PROTOPORPHYRIN+IX+CONTAINING+CO'>COH</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tzi OCA], [https://pdbe.org/3tzi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tzi RCSB], [https://www.ebi.ac.uk/pdbsum/3tzi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tzi ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PGH2_MOUSE PGH2_MOUSE] Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.<ref>PMID:12925531</ref> <ref>PMID:20463020</ref> <ref>PMID:20810665</ref> <ref>PMID:21489986</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Cyclooxygenase 3D structures|Cyclooxygenase 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Malkowski MG]] | ||
| + | [[Category: Vecchio AJ]] | ||
Current revision
X-ray crystal structure of arachidonic acid bound in the cyclooxygenase channel of G533V murine COX-2
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