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3u6x

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==Phage TP901-1 baseplate tripod==
==Phage TP901-1 baseplate tripod==
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<StructureSection load='3u6x' size='340' side='right' caption='[[3u6x]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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<StructureSection load='3u6x' size='340' side='right'caption='[[3u6x]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3u6x]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacteriophage_tp901-1 Bacteriophage tp901-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U6X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U6X FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3u6x]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactococcus_phage_TP901-1 Lactococcus phage TP901-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U6X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U6X FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ejc|3ejc]], [[2f0c|2f0c]], [[3uh8|3uh8]], [[4div|4div]], [[4diw|4diw]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">bpp, ORF49 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=35345 Bacteriophage TP901-1]), ORF48 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=35345 Bacteriophage TP901-1])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u6x OCA], [https://pdbe.org/3u6x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u6x RCSB], [https://www.ebi.ac.uk/pdbsum/3u6x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u6x ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u6x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u6x RCSB], [http://www.ebi.ac.uk/pdbsum/3u6x PDBsum]</span></td></tr>
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</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q9G096_9CAUD Q9G096_9CAUD]
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Phages of the Caudovirales order possess a tail that recognizes the host and ensures genome delivery upon infection. The X-ray structure of the approximately 1.8 MDa host adsorption device (baseplate) from the lactococcal phage TP901-1 shows that the receptor-binding proteins are pointing in the direction of the host, suggesting that this organelle is in a conformation ready for host adhesion. This result is in marked contrast with the lactococcal phage p2 situation, whose baseplate is known to undergo huge conformational changes in the presence of Ca(2+) to reach its active state. In vivo infection experiments confirmed these structural observations by demonstrating that Ca(2+) ions are required for host adhesion among p2-like phages (936-species) but have no influence on TP901-1-like phages (P335-species). These data suggest that these two families rely on diverse adhesion strategies which may lead to different signaling for genome release.
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Structure of the phage TP901-1 1.8 MDa baseplate suggests an alternative host adhesion mechanism.,Veesler D, Spinelli S, Mahony J, Lichiere J, Blangy S, Bricogne G, Legrand P, Ortiz-Lombardia M, Campanacci V, van Sinderen D, Cambillau C Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):8954-8. Epub 2012 May 18. PMID:22611190<ref>PMID:22611190</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacteriophage tp901-1]]
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[[Category: Lactococcus phage TP901-1]]
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[[Category: Blangy, S]]
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[[Category: Large Structures]]
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[[Category: Bricogne, G]]
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[[Category: Blangy S]]
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[[Category: Cambillau, C]]
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[[Category: Bricogne G]]
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[[Category: Campanacci, V I]]
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[[Category: Cambillau C]]
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[[Category: Legrand, P]]
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[[Category: Campanacci VI]]
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[[Category: Lichiere, J]]
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[[Category: Legrand P]]
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[[Category: Mahony, J]]
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[[Category: Lichiere J]]
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[[Category: Ortiz-Lombardia, M]]
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[[Category: Mahony J]]
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[[Category: Sinderen, D van]]
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[[Category: Ortiz-Lombardia M]]
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[[Category: Spinelli, S]]
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[[Category: Spinelli S]]
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[[Category: Veesler, D]]
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[[Category: Veesler D]]
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[[Category: Helix/beta]]
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[[Category: Van Sinderen D]]
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[[Category: Phage tail baseplate]]
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[[Category: Receptor binding complex]]
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[[Category: Viral protein]]
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Current revision

Phage TP901-1 baseplate tripod

PDB ID 3u6x

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