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3u7y

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[[Image:3u7y.jpg|left|200px]]
 
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==Structure of NIH45-46 Fab in complex with gp120 of 93TH057 HIV==
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The line below this paragraph, containing "STRUCTURE_3u7y", creates the "Structure Box" on the page.
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<StructureSection load='3u7y' size='340' side='right'caption='[[3u7y]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3u7y]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U7Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U7Y FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4478&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
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{{STRUCTURE_3u7y| PDB=3u7y | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u7y OCA], [https://pdbe.org/3u7y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u7y RCSB], [https://www.ebi.ac.uk/pdbsum/3u7y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u7y ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[https://omim.org/entry/254500 254500]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.
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== Function ==
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[https://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]
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===Structure of NIH45-46 Fab in complex with gp120 of 93TH057 HIV===
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==See Also==
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*[[Gp120 3D structures|Gp120 3D structures]]
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22033520 is the PubMed ID number.
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{{ABSTRACT_PUBMED_22033520}}
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==About this Structure==
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[[3u7y]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U7Y OCA].
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==Reference==
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<ref group="xtra">PMID:022033520</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
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[[Category: Bjorkman, P J.]]
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[[Category: Large Structures]]
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[[Category: Diskin, R.]]
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[[Category: Bjorkman PJ]]
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[[Category: Anti hiv]]
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[[Category: Diskin R]]
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[[Category: Glycosylation]]
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[[Category: Gp120]]
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[[Category: Ig fold]]
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[[Category: Viral protein-immune system complex]]
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Current revision

Structure of NIH45-46 Fab in complex with gp120 of 93TH057 HIV

PDB ID 3u7y

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