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3v03

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==Crystal structure of Bovine Serum Albumin==
==Crystal structure of Bovine Serum Albumin==
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<StructureSection load='3v03' size='340' side='right' caption='[[3v03]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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<StructureSection load='3v03' size='340' side='right'caption='[[3v03]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3v03]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V03 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V03 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3v03]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V03 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V03 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v03 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v03 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v03 RCSB], [http://www.ebi.ac.uk/pdbsum/3v03 PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v03 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v03 OCA], [https://pdbe.org/3v03 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v03 RCSB], [https://www.ebi.ac.uk/pdbsum/3v03 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v03 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/ALBU_BOVIN ALBU_BOVIN] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
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Serum albumin (SA) is the most abundant plasma protein in mammals. SA is a multifunctional protein with extraordinary ligand binding capacity, making it a transporter molecule for a diverse range of metabolites, drugs, nutrients, metals and other molecules. Due to its ligand binding properties, albumins have wide clinical, pharmaceutical, and biochemical applications. Albumins are also allergenic, and exhibit a high degree of cross-reactivity due to significant sequence and structure similarity of SAs from different organisms. Here we present crystal structures of albumins from cattle (BSA), horse (ESA) and rabbit (RSA) sera. The structural data are correlated with the results of immunological studies of SAs. We also analyze the conservation or divergence of structures and sequences of SAs in the context of their potential allergenicity and cross-reactivity. In addition, we identified a previously uncharacterized ligand binding site in the structure of RSA, and calcium binding sites in the structure of BSA, which is the first serum albumin structure to contain metal ions.
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Structural and immunologic characterization of bovine, horse, and rabbit serum albumins.,Majorek KA, Porebski PJ, Dayal A, Zimmerman MD, Jablonska K, Stewart AJ, Chruszcz M, Minor W Mol Immunol. 2012 Oct;52(3-4):174-82. Epub 2012 Jun 6. PMID:22677715<ref>PMID:22677715</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==See Also==
==See Also==
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*[[Albumin|Albumin]]
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*[[Albumin 3D structures|Albumin 3D structures]]
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Almo, S C]]
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[[Category: Large Structures]]
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[[Category: Chruszcz, M]]
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[[Category: Almo SC]]
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[[Category: Majorek, K A]]
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[[Category: Chruszcz M]]
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[[Category: Minor, W]]
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[[Category: Majorek KA]]
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[[Category: Structural genomic]]
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[[Category: Minor W]]
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[[Category: Porebski, P J]]
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[[Category: Porebski PJ]]
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[[Category: Allergen]]
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[[Category: Carrier protein]]
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[[Category: Nysgrc]]
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[[Category: Psi-biology]]
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[[Category: Transport protein]]
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Current revision

Crystal structure of Bovine Serum Albumin

PDB ID 3v03

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