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3v56

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[[Image:3v56.jpg|left|200px]]
 
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==Re-refinement of PDB entry 1OSG - Complex between BAFF and a BR3 derived peptide presented in a beta-hairpin scaffold - reveals an additonal copy of the peptide.==
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The line below this paragraph, containing "STRUCTURE_3v56", creates the "Structure Box" on the page.
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<StructureSection load='3v56' size='340' side='right'caption='[[3v56]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3v56]] is a 13 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V56 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V56 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3v56| PDB=3v56 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v56 OCA], [https://pdbe.org/3v56 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v56 RCSB], [https://www.ebi.ac.uk/pdbsum/3v56 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v56 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TN13B_HUMAN TN13B_HUMAN] Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.<ref>PMID:10973284</ref> Isoform 2 seems to inhibit isoform 1 secretion and bioactivity (By similarity).<ref>PMID:10973284</ref>
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===Re-refinement of PDB entry 1OSG - Complex between BAFF and a BR3 derived peptide presented in a beta-hairpin scaffold - reveals an additonal copy of the peptide.===
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==See Also==
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*[[Tumor necrosis factor ligand superfamily 3D structures|Tumor necrosis factor ligand superfamily 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 12755599 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_12755599}}
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==About this Structure==
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[[3v56]] is a 13 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V56 OCA].
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==Reference==
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<ref group="xtra">PMID:012755599</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bricogne, G.]]
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[[Category: Large Structures]]
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[[Category: Flensburg, C.]]
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[[Category: Bricogne G]]
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[[Category: Keller, P.]]
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[[Category: Flensburg C]]
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[[Category: Paciorek, W.]]
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[[Category: Keller P]]
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[[Category: Sharff, A.]]
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[[Category: Paciorek W]]
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[[Category: Smart, O S.]]
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[[Category: Sharff A]]
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[[Category: Vonrhein, C.]]
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[[Category: Smart OS]]
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[[Category: Womack, T O.]]
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[[Category: Vonrhein C]]
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[[Category: Beta hairpin]]
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[[Category: Womack TO]]
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[[Category: Immune system]]
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[[Category: Jelly-roll]]
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[[Category: Protein-peptide complex]]
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Current revision

Re-refinement of PDB entry 1OSG - Complex between BAFF and a BR3 derived peptide presented in a beta-hairpin scaffold - reveals an additonal copy of the peptide.

PDB ID 3v56

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