3v8d
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human CYP7A1 in complex with 7-ketocholesterol== | |
| - | + | <StructureSection load='3v8d' size='340' side='right'caption='[[3v8d]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3v8d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V8D FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0GV:(3BETA,8ALPHA,9BETA)-3-HYDROXYCHOLEST-5-EN-7-ONE'>0GV</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v8d OCA], [https://pdbe.org/3v8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v8d RCSB], [https://www.ebi.ac.uk/pdbsum/3v8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v8d ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CP7A1_HUMAN CP7A1_HUMAN] Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis.<ref>PMID:19965590</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith CH]] | ||
| + | [[Category: Bountra C]] | ||
| + | [[Category: Edwards AM]] | ||
| + | [[Category: MacKenzie F]] | ||
| + | [[Category: Park H]] | ||
| + | [[Category: Strushkevich N]] | ||
| + | [[Category: Tempel W]] | ||
| + | [[Category: Usanov SA]] | ||
| + | [[Category: Weigelt J]] | ||
| + | [[Category: Wernimont AK]] | ||
Current revision
Crystal structure of human CYP7A1 in complex with 7-ketocholesterol
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bountra C | Edwards AM | MacKenzie F | Park H | Strushkevich N | Tempel W | Usanov SA | Weigelt J | Wernimont AK
