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3v9h
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3v9h is ON HOLD Authors: Tanner, J.J., Singh, RK Description: Crystal structure of human 1-pyrroline-5-carboxylate dehydrogenase mutant S352A) |
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| - | '''Unreleased structure''' | ||
| - | The entry | + | ==Crystal structure of human 1-pyrroline-5-carboxylate dehydrogenase mutant S352A== |
| + | <StructureSection load='3v9h' size='340' side='right'caption='[[3v9h]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3v9h]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V9H FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v9h OCA], [https://pdbe.org/3v9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v9h RCSB], [https://www.ebi.ac.uk/pdbsum/3v9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v9h ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/AL4A1_HUMAN AL4A1_HUMAN] Hyperprolinemia type 2. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/AL4A1_HUMAN AL4A1_HUMAN] Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes.<ref>PMID:22516612</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Aldehyde dehydrogenase 3D structures|Aldehyde dehydrogenase 3D structures]] | |
| - | + | *[[Pyrroline-5-carboxylate dehydrogenase|Pyrroline-5-carboxylate dehydrogenase]] | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Singh RK]] | ||
| + | [[Category: Tanner JJ]] | ||
Current revision
Crystal structure of human 1-pyrroline-5-carboxylate dehydrogenase mutant S352A
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