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3v9i

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[[Image:3v9i.png|left|200px]]
 
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{{STRUCTURE_3v9i| PDB=3v9i | SCENE= }}
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==Crystal structure of human 1-pyrroline-5-carboxylate dehydrogenase mutant S352L==
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<StructureSection load='3v9i' size='340' side='right'caption='[[3v9i]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3v9i]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V9I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V9I FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v9i OCA], [https://pdbe.org/3v9i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v9i RCSB], [https://www.ebi.ac.uk/pdbsum/3v9i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v9i ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/AL4A1_HUMAN AL4A1_HUMAN] Hyperprolinemia type 2. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/AL4A1_HUMAN AL4A1_HUMAN] Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes.<ref>PMID:22516612</ref>
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===Crystal structure of human 1-pyrroline-5-carboxylate dehydrogenase mutant S352L===
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==See Also==
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*[[Aldehyde dehydrogenase 3D structures|Aldehyde dehydrogenase 3D structures]]
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{{ABSTRACT_PUBMED_22516612}}
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*[[Pyrroline-5-carboxylate dehydrogenase|Pyrroline-5-carboxylate dehydrogenase]]
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== References ==
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==About this Structure==
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<references/>
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[[3v9i]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V9I OCA].
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__TOC__
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:022516612</ref><references group="xtra"/>
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[[Category: 1-pyrroline-5-carboxylate dehydrogenase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Singh, R K.]]
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[[Category: Large Structures]]
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[[Category: Tanner, J J.]]
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[[Category: Singh RK]]
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[[Category: Acting on aldehyde or oxo group of donor]]
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[[Category: Tanner JJ]]
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[[Category: Aldehyde dehydrogenase]]
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[[Category: Mitochondria]]
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[[Category: Nad or nadp as acceptor]]
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[[Category: Nucleotide binding]]
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[[Category: Oxidoreductase]]
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[[Category: Rossmann fold]]
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Current revision

Crystal structure of human 1-pyrroline-5-carboxylate dehydrogenase mutant S352L

PDB ID 3v9i

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