This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3vdl

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "3vdl" [edit=sysop:move=sysop])
Current revision (14:25, 14 March 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 3vdl is ON HOLD
+
==Crystal structure of circumsporozoite protein aTSR domain, P43212 form==
-
 
+
<StructureSection load='3vdl' size='340' side='right'caption='[[3vdl]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
-
Authors: Doud, M.B., Koksal, A.C., Mi, L.Z., Song, G., Springer, T.A.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[3vdl]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VDL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VDL FirstGlance]. <br>
-
Description: A novel fold in the circumsporozoite protein target of malaria vaccines
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.04&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vdl OCA], [https://pdbe.org/3vdl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vdl RCSB], [https://www.ebi.ac.uk/pdbsum/3vdl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vdl ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/CSP_PLAF7 CSP_PLAF7] Essential sporozoite protein (PubMed:29554084, PubMed:32150583). In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands (By similarity). In the vertebrate host, required for sporozoite migration through the host dermis and infection of host hepatocytes (PubMed:29554084, PubMed:32150583). Binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes (By similarity).[UniProtKB:P23093]<ref>PMID:29554084</ref> <ref>PMID:32150583</ref> In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.[UniProtKB:P23093]
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
 +
[[Category: Plasmodium falciparum 3D7]]
 +
[[Category: Doud MB]]
 +
[[Category: Koksal AC]]
 +
[[Category: Lu C]]
 +
[[Category: Mi LZ]]
 +
[[Category: Song G]]
 +
[[Category: Springer TA]]

Current revision

Crystal structure of circumsporozoite protein aTSR domain, P43212 form

PDB ID 3vdl

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3vdl"
Personal tools