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3vfv

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[[Image:3vfv.jpg|left|200px]]
 
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==crystal structure of HLA B*3508 LPEP-P9Ala, peptide mutant P9-ala==
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The line below this paragraph, containing "STRUCTURE_3vfv", creates the "Structure Box" on the page.
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<StructureSection load='3vfv' size='340' side='right'caption='[[3vfv]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3vfv]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VFV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VFV FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vfv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vfv OCA], [https://pdbe.org/3vfv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vfv RCSB], [https://www.ebi.ac.uk/pdbsum/3vfv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vfv ProSAT]</span></td></tr>
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{{STRUCTURE_3vfv| PDB=3vfv | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[https://omim.org/entry/241600 241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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===Crystal Structure of peptide-HLA complex, peptide mutant===
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==See Also==
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*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
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*[[MHC 3D structures|MHC 3D structures]]
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==About this Structure==
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*[[MHC I 3D structures|MHC I 3D structures]]
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[[3vfv]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VFV OCA].
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Gras, S.]]
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[[Category: Large Structures]]
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[[Category: Liu, Y C.]]
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[[Category: Gras S]]
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[[Category: Rossjohn, J.]]
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[[Category: Liu YC]]
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[[Category: Antigen-presenting molecule]]
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[[Category: Rossjohn J]]
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[[Category: Epstein barr virus]]
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[[Category: Hla b*3508]]
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[[Category: Immune system]]
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[[Category: T cell]]
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[[Category: Tcr]]
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Current revision

crystal structure of HLA B*3508 LPEP-P9Ala, peptide mutant P9-ala

PDB ID 3vfv

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