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4dag

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==Structure of the Human Metapneumovirus Fusion Protein with Neutralizing Antibody Identifies a Pneumovirus Antigenic Site==
==Structure of the Human Metapneumovirus Fusion Protein with Neutralizing Antibody Identifies a Pneumovirus Antigenic Site==
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<StructureSection load='4dag' size='340' side='right' caption='[[4dag]], [[Resolution|resolution]] 3.39&Aring;' scene=''>
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<StructureSection load='4dag' size='340' side='right'caption='[[4dag]], [[Resolution|resolution]] 3.39&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4dag]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_metapneumovirus Human metapneumovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DAG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DAG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4dag]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_metapneumovirus Human metapneumovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DAG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DAG FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3904&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IGHG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), IGL@ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dag FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dag OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dag RCSB], [http://www.ebi.ac.uk/pdbsum/4dag PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dag FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dag OCA], [https://pdbe.org/4dag PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dag RCSB], [https://www.ebi.ac.uk/pdbsum/4dag PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dag ProSAT]</span></td></tr>
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<table>
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</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/G3KCK8_9MONO G3KCK8_9MONO]
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Human metapneumovirus and respiratory syncytial virus cause lower respiratory tract infections. The virus fusion (F) glycoprotein promotes membrane fusion by refolding from a metastable pre-fusion to a stable post-fusion conformation. F is also a major target of the neutralizing antibody response. Here we show that a potently neutralizing anti-human metapneumovirus antibody (DS7) binds a structurally invariant domain of F, revealing a new epitope that could be targeted in vaccine development.
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Structure of the human metapneumovirus fusion protein with neutralizing antibody identifies a pneumovirus antigenic site.,Wen X, Krause JC, Leser GP, Cox RG, Lamb RA, Williams JV, Crowe JE Jr, Jardetzky TS Nat Struct Mol Biol. 2012 Mar 4. doi: 10.1038/nsmb.2250. PMID:22388735<ref>PMID:22388735</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==See Also==
==See Also==
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*[[Antibody|Antibody]]
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*[[Antibody 3D structures|Antibody 3D structures]]
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== References ==
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*[[3D structures of human antibody|3D structures of human antibody]]
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Human metapneumovirus]]
[[Category: Human metapneumovirus]]
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[[Category: Jardetzky, T S.]]
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[[Category: Large Structures]]
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[[Category: Wen, X.]]
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[[Category: Jardetzky TS]]
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[[Category: Antibody]]
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[[Category: Wen X]]
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[[Category: Ds7]]
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[[Category: Ds7 antibody structure]]
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[[Category: Fab structure]]
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[[Category: Immune system]]
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[[Category: Mpv fusion protein]]
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[[Category: Vaccine]]
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[[Category: Viral protein]]
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[[Category: Viral protein-immune system complex]]
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Current revision

Structure of the Human Metapneumovirus Fusion Protein with Neutralizing Antibody Identifies a Pneumovirus Antigenic Site

PDB ID 4dag

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