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4daj

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[[Image:4daj.png|left|200px]]
 
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==Structure of the M3 Muscarinic Acetylcholine Receptor==
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The line below this paragraph, containing "STRUCTURE_4daj", creates the "Structure Box" on the page.
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<StructureSection load='4daj' size='340' side='right'caption='[[4daj]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4daj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DAJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DAJ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0HK:(1R,2R,4S,5S,7S)-7-{[HYDROXY(DITHIOPHEN-2-YL)ACETYL]OXY}-9,9-DIMETHYL-3-OXA-9-AZONIATRICYCLO[3.3.1.0~2,4~]NONANE'>0HK</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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{{STRUCTURE_4daj| PDB=4daj | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4daj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4daj OCA], [https://pdbe.org/4daj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4daj RCSB], [https://www.ebi.ac.uk/pdbsum/4daj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4daj ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref> [https://www.uniprot.org/uniprot/ACM3_RAT ACM3_RAT] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.<ref>PMID:1527051</ref> <ref>PMID:1657592</ref> <ref>PMID:22358844</ref>
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===Structure of the M3 Muscarinic Acetylcholine Receptor===
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==See Also==
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*[[Lysozyme 3D structures|Lysozyme 3D structures]]
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*[[Muscarinic acetylcholine receptor|Muscarinic acetylcholine receptor]]
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== References ==
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The line below this paragraph, {{ABSTRACT_PUBMED_22358844}}, adds the Publication Abstract to the page
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<references/>
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(as it appears on PubMed at http://www.pubmed.gov), where 22358844 is the PubMed ID number.
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__TOC__
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</StructureSection>
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{{ABSTRACT_PUBMED_22358844}}
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[[Category: Escherichia virus T4]]
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[[Category: Large Structures]]
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==About this Structure==
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[[Category: Rattus norvegicus]]
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[[4daj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus,_enterobacteria_phage_t4 Rattus norvegicus, enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DAJ OCA].
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[[Category: Arlow DH]]
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[[Category: Chae PS]]
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==Reference==
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[[Category: Dror RO]]
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<ref group="xtra">PMID:022358844</ref><references group="xtra"/>
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[[Category: Green HF]]
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[[Category: Lysozyme]]
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[[Category: Hu J]]
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[[Category: Rattus norvegicus, enterobacteria phage t4]]
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[[Category: Kobilka B]]
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[[Category: Arlow, D H.]]
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[[Category: Kruse AC]]
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[[Category: Chae, P S.]]
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[[Category: Liu T]]
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[[Category: Dror, R O.]]
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[[Category: Pan AC]]
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[[Category: Green, H F.]]
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[[Category: Rosemond E]]
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[[Category: Hu, J.]]
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[[Category: Rosenbaum DM]]
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[[Category: Kobilka, B.]]
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[[Category: Shaw DE]]
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[[Category: Kruse, A C.]]
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[[Category: Weis WI]]
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[[Category: Liu, T.]]
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[[Category: Wess J]]
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[[Category: Pan, A C.]]
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[[Category: Rosemond, E.]]
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[[Category: Rosenbaum, D M.]]
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[[Category: Shaw, D E.]]
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[[Category: Weis, W I.]]
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[[Category: Wess, J.]]
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[[Category: Acetylcholine receptor]]
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[[Category: G protein-coupled receptor]]
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[[Category: Hydrolase]]
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[[Category: Muscarinic receptor]]
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[[Category: Signaling protein]]
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Current revision

Structure of the M3 Muscarinic Acetylcholine Receptor

PDB ID 4daj

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OCA

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