This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4daj

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (14:29, 14 March 2024) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:4daj.png|left|200px]]
 
-
{{STRUCTURE_4daj| PDB=4daj | SCENE= }}
+
==Structure of the M3 Muscarinic Acetylcholine Receptor==
-
 
+
<StructureSection load='4daj' size='340' side='right'caption='[[4daj]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
-
===Structure of the M3 Muscarinic Acetylcholine Receptor===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[4daj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DAJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DAJ FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_22358844}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0HK:(1R,2R,4S,5S,7S)-7-{[HYDROXY(DITHIOPHEN-2-YL)ACETYL]OXY}-9,9-DIMETHYL-3-OXA-9-AZONIATRICYCLO[3.3.1.0~2,4~]NONANE'>0HK</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4daj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4daj OCA], [https://pdbe.org/4daj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4daj RCSB], [https://www.ebi.ac.uk/pdbsum/4daj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4daj ProSAT]</span></td></tr>
-
[[4daj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DAJ OCA].
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref> [https://www.uniprot.org/uniprot/ACM3_RAT ACM3_RAT] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.<ref>PMID:1527051</ref> <ref>PMID:1657592</ref> <ref>PMID:22358844</ref>
==See Also==
==See Also==
-
*[[G protein-coupled receptor|G protein-coupled receptor]]
+
*[[Lysozyme 3D structures|Lysozyme 3D structures]]
-
 
+
*[[Muscarinic acetylcholine receptor|Muscarinic acetylcholine receptor]]
-
==Reference==
+
== References ==
-
<ref group="xtra">PMID:022358844</ref><references group="xtra"/>
+
<references/>
-
[[Category: Enterobacteria phage t4]]
+
__TOC__
-
[[Category: Lysozyme]]
+
</StructureSection>
-
[[Category: Arlow, D H.]]
+
[[Category: Escherichia virus T4]]
-
[[Category: Chae, P S.]]
+
[[Category: Large Structures]]
-
[[Category: Dror, R O.]]
+
[[Category: Rattus norvegicus]]
-
[[Category: Green, H F.]]
+
[[Category: Arlow DH]]
-
[[Category: Hu, J.]]
+
[[Category: Chae PS]]
-
[[Category: Kobilka, B.]]
+
[[Category: Dror RO]]
-
[[Category: Kruse, A C.]]
+
[[Category: Green HF]]
-
[[Category: Liu, T.]]
+
[[Category: Hu J]]
-
[[Category: Pan, A C.]]
+
[[Category: Kobilka B]]
-
[[Category: Rosemond, E.]]
+
[[Category: Kruse AC]]
-
[[Category: Rosenbaum, D M.]]
+
[[Category: Liu T]]
-
[[Category: Shaw, D E.]]
+
[[Category: Pan AC]]
-
[[Category: Weis, W I.]]
+
[[Category: Rosemond E]]
-
[[Category: Wess, J.]]
+
[[Category: Rosenbaum DM]]
-
[[Category: Acetylcholine receptor]]
+
[[Category: Shaw DE]]
-
[[Category: G protein-coupled receptor]]
+
[[Category: Weis WI]]
-
[[Category: Hydrolase]]
+
[[Category: Wess J]]
-
[[Category: Muscarinic receptor]]
+
-
[[Category: Signaling protein]]
+

Current revision

Structure of the M3 Muscarinic Acetylcholine Receptor

PDB ID 4daj

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4daj"
Personal tools