4dd8

<StructureSection load='4dd8' size='340' side='right' caption='[[4dd8]], [[Resolution|resolution]] 2.10&Aring;' scene=''>

<table><tr><td colspan='2'>[[4dd8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DD8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DD8 FirstGlance]. <br>

</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BAT:4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE'>BAT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>

<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ADAM8, MS2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>

<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dd8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dd8 RCSB], [http://www.ebi.ac.uk/pdbsum/4dd8 PDBsum]</span></td></tr>

<table>

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== Publication Abstract from PubMed ==

The role of ADAM-8 in cancer and inflammatory diseases such as allergy, arthritis and asthma makes it an attractive target for drug development. Therefore, the catalytic domain of human ADAM-8 was expressed, purified and crystallized in complex with a hydroxamic acid inhibitor, batimastat. The crystal structure of the enzyme-inhibitor complex was refined to 2.1 A resolution. ADAM-8 has an overall fold similar to those of other ADAM members, including a central five-stranded beta-sheet and a catalytic Zn(2+) ion. However, unique differences within the S1' binding loop of ADAM-8 are observed which might be exploited to confer specificity and selectivity to ADAM-8 competitive inhibitors for the treatment of diseases involving this enzyme.

 

== References ==

[[Category: Caspers, N.]]

[[Category: Chrencik, J E.]]

[[Category: Day, J E.]]

[[Category: Fischer, D H.]]

[[Category: Hall, T.]]

[[Category: Kiefer, J R.]]

[[Category: Krahn, J M.]]

[[Category: Moon, A F.]]

[[Category: Pauley, A M.]]

[[Category: Pegg, L E.]]

[[Category: Shieh, H S.]]

[[Category: Tomasselli, A G.]]

[[Category: Williams, J M.]]

[[Category: Zack, M D.]]

[[Category: Tumorigenesis]]