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4dgr
From Proteopedia
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| - | [[Image:4dgr.png|left|200px]] | ||
| - | + | ==Influenza Subtype 9 Neuraminidase Benzoic Acid Inhibitor Complex== | |
| - | + | <StructureSection load='4dgr' size='340' side='right'caption='[[4dgr]], [[Resolution|resolution]] 1.55Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4dgr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/tern/Australia/G70C/1975(H11N9)) Influenza A virus (A/tern/Australia/G70C/1975(H11N9))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DGR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.551Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3LV:4-[2,2-BIS(HYDROXYMETHYL)-5-OXOPYRROLIDIN-1-YL]-3-[(DIPROPYLAMINO)METHYL]BENZOIC+ACID'>3LV</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dgr OCA], [https://pdbe.org/4dgr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dgr RCSB], [https://www.ebi.ac.uk/pdbsum/4dgr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dgr ProSAT]</span></td></tr> |
| - | [[4dgr]] is a 1 chain structure | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NRAM_I75A5 NRAM_I75A5] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication. | ||
==See Also== | ==See Also== | ||
| - | *[[Neuraminidase|Neuraminidase]] | + | *[[Neuraminidase 3D structures|Neuraminidase 3D structures]] |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Large Structures]] | |
| - | [[Category: | + | [[Category: Air GM]] |
| - | + | [[Category: Brouillette W]] | |
| - | [[Category: Air | + | [[Category: Johnson E]] |
| - | [[Category: Brouillette | + | [[Category: Kolavi G]] |
| - | [[Category: Johnson | + | [[Category: Mooers BHM]] |
| - | [[Category: Kolavi | + | [[Category: Venkatramani L]] |
| - | [[Category: Mooers | + | |
| - | [[Category: Venkatramani | + | |
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Current revision
Influenza Subtype 9 Neuraminidase Benzoic Acid Inhibitor Complex
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