This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4djz

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (14:36, 14 March 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:4djz.jpg|left|200px]]
 
-
<!--
+
==Catalytic fragment of masp-1 in complex with its specific inhibitor developed by directed evolution on sgci scaffold==
-
The line below this paragraph, containing "STRUCTURE_4djz", creates the "Structure Box" on the page.
+
<StructureSection load='4djz' size='340' side='right'caption='[[4djz]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[4djz]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Schistocerca_gregaria Schistocerca gregaria]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DJZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DJZ FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4djz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4djz OCA], [https://pdbe.org/4djz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4djz RCSB], [https://www.ebi.ac.uk/pdbsum/4djz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4djz ProSAT]</span></td></tr>
-
{{STRUCTURE_4djz| PDB=4djz | SCENE= }}
+
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/MASP1_HUMAN MASP1_HUMAN] Defects in MASP1 are the cause of 3MC syndrome type 1 (3MC1) [MIM:[https://omim.org/entry/257920 257920]. 3MC1 is a disorder characterized by facial dysmorphism that includes hypertelorism, blepharophimosis, blepharoptosis and highly arched eyebrows, cleft lip and/or palate, craniosynostosis, learning disability and genital, limb and vesicorenal anomalies. The term 3MC syndrome includes Carnevale, Mingarelli, Malpuech, and Michels syndromes.<ref>PMID:21258343</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/MASP1_HUMAN MASP1_HUMAN] Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5.<ref>PMID:11485744</ref> <ref>PMID:17182967</ref>
-
===Catalytic fragment of masp-1 in complex with its specific inhibitor developed by directed evolution on sgci scaffold===
+
==See Also==
-
 
+
*[[Mannan-binding lectin serine protease|Mannan-binding lectin serine protease]]
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
[[4djz]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Schistocerca_gregaria Schistocerca gregaria]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DJZ OCA].
+
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
[[Category: Schistocerca gregaria]]
[[Category: Schistocerca gregaria]]
-
[[Category: Dobo, J.]]
+
[[Category: Dobo J]]
-
[[Category: Fodor, K.]]
+
[[Category: Fodor K]]
-
[[Category: Gal, P.]]
+
[[Category: Gal P]]
-
[[Category: Harmat, V.]]
+
[[Category: Harmat V]]
-
[[Category: Heja, D.]]
+
[[Category: Heja D]]
-
[[Category: Kekesi, K A.]]
+
[[Category: Kekesi KA]]
-
[[Category: Pal, G.]]
+
[[Category: Pal G]]
-
[[Category: Wilmanns, M.]]
+
[[Category: Wilmanns M]]
-
[[Category: Zavodszky, P.]]
+
[[Category: Zavodszky P]]
-
[[Category: Hydrolase]]
+
-
[[Category: Hydrolase-hydrolase inhibitor complex]]
+
-
[[Category: In vitro evolution]]
+
-
[[Category: Specific inhibitor]]
+

Current revision

Catalytic fragment of masp-1 in complex with its specific inhibitor developed by directed evolution on sgci scaffold

PDB ID 4djz

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4djz"
Personal tools