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4dq4

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==Bovine beta-lactoglobulin complex with linoleic acid==
==Bovine beta-lactoglobulin complex with linoleic acid==
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<StructureSection load='4dq4' size='340' side='right' caption='[[4dq4]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='4dq4' size='340' side='right'caption='[[4dq4]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4dq4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3qzk 3qzk]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DQ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DQ4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4dq4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3qzk 3qzk]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DQ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DQ4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EIC:LINOLEIC+ACID'>EIC</scene>, <scene name='pdbligand=EOH:ETHANOL'>EOH</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3npo|3npo]], [[3nq3|3nq3]], [[3nq9|3nq9]], [[4dq3|4dq3]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EIC:LINOLEIC+ACID'>EIC</scene>, <scene name='pdbligand=EOH:ETHANOL'>EOH</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dq4 OCA], [http://pdbe.org/4dq4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4dq4 RCSB], [http://www.ebi.ac.uk/pdbsum/4dq4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4dq4 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dq4 OCA], [https://pdbe.org/4dq4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dq4 RCSB], [https://www.ebi.ac.uk/pdbsum/4dq4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dq4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LACB_BOVIN LACB_BOVIN]] Primary component of whey, it binds retinol and is probably involved in the transport of that molecule.
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[https://www.uniprot.org/uniprot/LACB_BOVIN LACB_BOVIN] Primary component of whey, it binds retinol and is probably involved in the transport of that molecule.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Binding of 18-carbon unsaturated oleic and linoleic acid to lactoglobulin, the milk protein, has been studied for the first time by isothermal titration calorimetry (ITC) and X-ray crystallography. Crystal structures determined to resolution 2.10A have revealed presence of single fatty acid molecule bound in ss-barrel, the primary binding site, with carboxyl group hydrogen bonded to Glu62. The aliphatic chain of both ligands is in almost linear conformation and their interactions with the protein are similar to observed in structure of lactoglobulin with stearic acid. The ITC experiments showed that binding of unsaturated fatty acids to LGB is spontaneous and exothermic. The stoichiometry of binding is lower than 1.0, association constant is 9.7x105M-1 and 9.0x105M-1 for oleic and linoleic acid, respectively. Solvent relief seems to be the major contributor to entropic changes upon fatty acid binding to lactoglobulin.
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Binding of 18-carbon unsaturated fatty acids to bovine ss-lactoglobulin-Structural and thermodynamic studies.,Loch JI, Bonarek P, Polit A, Ries D, Dziedzicka-Wasylewska M, Lewinski K Int J Biol Macromol. 2013 Mar 15. pii: S0141-8130(13)00107-4. doi:, 10.1016/j.ijbiomac.2013.03.021. PMID:23500663<ref>PMID:23500663</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4dq4" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
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*[[Beta-lactoglobulin|Beta-lactoglobulin]]
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*[[Beta-lactoglobulin 3D structures|Beta-lactoglobulin 3D structures]]
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Lewinski, K]]
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[[Category: Large Structures]]
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[[Category: Loch, J I]]
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[[Category: Lewinski K]]
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[[Category: Bovine milk]]
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[[Category: Loch JI]]
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[[Category: Lipocalin]]
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[[Category: Transport protein]]
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Current revision

Bovine beta-lactoglobulin complex with linoleic acid

PDB ID 4dq4

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