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4dtg
From Proteopedia
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| - | [[Image:4dtg.png|left|200px]] | ||
| - | + | ==Hemostatic effect of a monoclonal antibody mAb 2021 blocking the interaction between FXa and TFPI in a rabbit hemophilia model== | |
| + | <StructureSection load='4dtg' size='340' side='right'caption='[[4dtg]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4dtg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DTG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DTG FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dtg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dtg OCA], [https://pdbe.org/4dtg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dtg RCSB], [https://www.ebi.ac.uk/pdbsum/4dtg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dtg ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TFPI1_HUMAN TFPI1_HUMAN] Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma. | ||
| - | == | + | ==See Also== |
| - | + | *[[Antibody 3D structures|Antibody 3D structures]] | |
| - | + | *[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]] | |
| - | + | *[[Tissue factor pathway inhibitor|Tissue factor pathway inhibitor]] | |
| - | + | *[[3D structures of human antibody|3D structures of human antibody]] | |
| - | [[ | + | __TOC__ |
| - | + | </StructureSection> | |
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| - | < | + | |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Breinholt J]] |
| - | [[Category: | + | [[Category: Hilden I]] |
| - | [[Category: | + | [[Category: Krogh BO]] |
| - | [[Category: | + | [[Category: Svensson LA]] |
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Current revision
Hemostatic effect of a monoclonal antibody mAb 2021 blocking the interaction between FXa and TFPI in a rabbit hemophilia model
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