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4dvt

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{{STRUCTURE_4dvt| PDB=4dvt | SCENE= }}
 
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===Crystal structure of clade A/E 93TH057 HIV-1 gp120 core in complex with AS-II-37===
 
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{{ABSTRACT_PUBMED_24489681}}
 
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==Function==
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==Crystal structure of clade A/E 93TH057 HIV-1 gp120 core in complex with AS-II-37==
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[[http://www.uniprot.org/uniprot/Q0ED31_9HIV1 Q0ED31_9HIV1]] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity).[RuleBase:RU004292][SAAS:SAAS000328_004_020447] The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).
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<StructureSection load='4dvt' size='340' side='right'caption='[[4dvt]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4dvt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DVT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DVT FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0LZ:N-(4-CHLORO-3-FLUOROPHENYL)-N-[(1S)-1,2,3,4-TETRAHYDROISOQUINOLIN-1-YLMETHYL]ETHANEDIAMIDE'>0LZ</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dvt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dvt OCA], [https://pdbe.org/4dvt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dvt RCSB], [https://www.ebi.ac.uk/pdbsum/4dvt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dvt ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A0A0M3KKW9_9HIV1 A0A0M3KKW9_9HIV1]
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==About this Structure==
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==See Also==
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[[4dvt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DVT OCA].
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*[[Gp120 3D structures|Gp120 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:024489681</ref><references group="xtra"/><references/>
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[[Category: Human immunodeficiency virus 1]]
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[[Category: 9hiv1]]
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[[Category: Large Structures]]
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[[Category: Kwon,Y D.]]
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[[Category: Kwon YD]]
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[[Category: Kwong, P D.]]
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[[Category: Kwong PD]]
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[[Category: As-ii-37]]
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[[Category: Cd4 binding site]]
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[[Category: Hiv-1 gp120]]
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[[Category: Small molecule inhibitor]]
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[[Category: Viral protein-transcription inhibitor complex]]
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Current revision

Crystal structure of clade A/E 93TH057 HIV-1 gp120 core in complex with AS-II-37

PDB ID 4dvt

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