This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4dwc

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (14:46, 14 March 2024) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:4dwc.jpg|left|200px]]
 
-
<!--
+
==Crystal structure of the glycoprotein Erns from the pestivirus BVDV-1 in complex with Zn ions==
-
The line below this paragraph, containing "STRUCTURE_4dwc", creates the "Structure Box" on the page.
+
<StructureSection load='4dwc' size='340' side='right'caption='[[4dwc]], [[Resolution|resolution]] 2.89&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[4dwc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovine_viral_diarrhea_virus_1-CP7 Bovine viral diarrhea virus 1-CP7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DWC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DWC FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.89&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FCA:ALPHA-D-FUCOSE'>FCA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
{{STRUCTURE_4dwc| PDB=4dwc | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dwc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dwc OCA], [https://pdbe.org/4dwc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dwc RCSB], [https://www.ebi.ac.uk/pdbsum/4dwc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dwc ProSAT]</span></td></tr>
-
 
+
</table>
-
===Crystal structure of the glycoprotein Erns from the pestivirus BVDV-1 in complex with Zn ions===
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/POLG_BVDVC POLG_BVDVC] Initial binding to target cell probably involves interaction of E(rns) with glycosaminoglycans. E1 and/or E2 are responsible of cell attachment with CD46 and subsequent fusion after internalization of the virion by endocytosis (By similarity). P7 forms a leader sequence to properly orient NS2 in the membrane (By similarity). Uncleaved NS2-3 is required for production of infectious virus. NS2 protease seems to play a vital role in viral RNA replication control and in the pathogenicity of the virus. NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS4A is a cofactor for the NS3 protease activity (By similarity). RNA-directed RNA polymerase NS5 replicates the viral (+) and (-) genome.
-
 
+
__TOC__
-
<!--
+
</StructureSection>
-
The line below this paragraph, {{ABSTRACT_PUBMED_22579253}}, adds the Publication Abstract to the page
+
[[Category: Bovine viral diarrhea virus 1-CP7]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 22579253 is the PubMed ID number.
+
[[Category: Large Structures]]
-
-->
+
[[Category: Bontems F]]
-
{{ABSTRACT_PUBMED_22579253}}
+
[[Category: Bricogne G]]
-
 
+
[[Category: Krey T]]
-
==About this Structure==
+
[[Category: Rey FA]]
-
[[4dwc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovine_viral_diarrhea_virus_1 Bovine viral diarrhea virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DWC OCA].
+
[[Category: Ruemenapf T]]
-
 
+
[[Category: Vaney M-C]]
-
==Reference==
+
[[Category: Vonrhein C]]
-
<ref group="xtra">PMID:022579253</ref><references group="xtra"/>
+
-
[[Category: Bovine viral diarrhea virus 1]]
+
-
[[Category: Bontems, F.]]
+
-
[[Category: Bricogne, G.]]
+
-
[[Category: Krey, T.]]
+
-
[[Category: Rey, F A.]]
+
-
[[Category: Ruemenapf, T.]]
+
-
[[Category: Vaney, M C.]]
+
-
[[Category: Vonrhein, C.]]
+
-
[[Category: T2 ribonuclease]]
+
-
[[Category: Viral protein]]
+
-
[[Category: Virus glycoprotein]]
+

Current revision

Crystal structure of the glycoprotein Erns from the pestivirus BVDV-1 in complex with Zn ions

PDB ID 4dwc

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4dwc"
Personal tools