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4e0s
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of C5b-6== | |
| + | <StructureSection load='4e0s' size='340' side='right'caption='[[4e0s]], [[Resolution|resolution]] 4.21Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4e0s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E0S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E0S FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.21Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e0s OCA], [https://pdbe.org/4e0s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e0s RCSB], [https://www.ebi.ac.uk/pdbsum/4e0s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e0s ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/CO6_HUMAN CO6_HUMAN] Defects in C6 are the cause of complement component 6 deficiency (C6D) [MIM:[https://omim.org/entry/612446 612446]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CO6_HUMAN CO6_HUMAN] Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. | ||
| - | + | ==See Also== | |
| - | + | *[[Complement C5 3D structures|Complement C5 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Aleshin AE]] | ||
| + | [[Category: DiScipio R]] | ||
| + | [[Category: Liddington RC]] | ||
| + | [[Category: Stec B]] | ||
Current revision
Crystal Structure of C5b-6
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