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4e0s

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[[Image:4e0s.png|left|200px]]
 
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==Crystal Structure of C5b-6==
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The line below this paragraph, containing "STRUCTURE_4e0s", creates the "Structure Box" on the page.
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<StructureSection load='4e0s' size='340' side='right'caption='[[4e0s]], [[Resolution|resolution]] 4.21&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4e0s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E0S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E0S FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.21&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_4e0s| PDB=4e0s | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e0s OCA], [https://pdbe.org/4e0s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e0s RCSB], [https://www.ebi.ac.uk/pdbsum/4e0s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e0s ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CO6_HUMAN CO6_HUMAN] Defects in C6 are the cause of complement component 6 deficiency (C6D) [MIM:[https://omim.org/entry/612446 612446]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
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== Function ==
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[https://www.uniprot.org/uniprot/CO6_HUMAN CO6_HUMAN] Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
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===Crystal Structure of C5b-6===
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==See Also==
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*[[Complement C5 3D structures|Complement C5 3D structures]]
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__TOC__
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 22500023 is the PubMed ID number.
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{{ABSTRACT_PUBMED_22500023}}
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==About this Structure==
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[[4e0s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E0S OCA].
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==Reference==
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<ref group="xtra">PMID:022500023</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Aleshin, A E.]]
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[[Category: Large Structures]]
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[[Category: DiScipio, R.]]
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[[Category: Aleshin AE]]
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[[Category: Liddington, R C.]]
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[[Category: DiScipio R]]
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[[Category: Stec, B.]]
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[[Category: Liddington RC]]
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[[Category: Complement]]
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[[Category: Stec B]]
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[[Category: Immune system]]
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[[Category: Mac]]
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Current revision

Crystal Structure of C5b-6

PDB ID 4e0s

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