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4e0w

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[[Image:4e0w.jpg|left|200px]]
 
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==Crystal structure of the kainate receptor GluK3 ligand binding domain in complex with kainate==
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The line below this paragraph, containing "STRUCTURE_4e0w", creates the "Structure Box" on the page.
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<StructureSection load='4e0w' size='340' side='right'caption='[[4e0w]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4e0w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E0W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E0W FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3501&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=KAI:3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE'>KAI</scene></td></tr>
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{{STRUCTURE_4e0w| PDB=4e0w | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e0w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e0w OCA], [https://pdbe.org/4e0w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e0w RCSB], [https://www.ebi.ac.uk/pdbsum/4e0w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e0w ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GRIK3_RAT GRIK3_RAT] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA.<ref>PMID:21907808</ref>
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===Crystal structure of the kainate receptor GluK3 ligand binding domain in complex with kainate===
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==See Also==
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*[[Glutamate receptor 3D structures|Glutamate receptor 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22425692 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_22425692}}
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==About this Structure==
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[[4e0w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E0W OCA].
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==Reference==
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<ref group="xtra">PMID:022425692</ref><ref group="xtra">PMID:021907808</ref><references group="xtra"/>
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Frydenvang, K.]]
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[[Category: Frydenvang K]]
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[[Category: Kastrup, J S.]]
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[[Category: Kastrup JS]]
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[[Category: Venskutonyte, R.]]
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[[Category: Venskutonyte R]]
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[[Category: Agonist]]
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[[Category: Gluk3]]
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[[Category: Ionotropic glutamate receptor]]
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[[Category: Ligand-binding domain]]
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[[Category: Membrane protein]]
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Current revision

Crystal structure of the kainate receptor GluK3 ligand binding domain in complex with kainate

PDB ID 4e0w

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