4e4v
From Proteopedia
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==The crystal structure of the dimeric human importin alpha 1 at 2.5 angstrom resolution.== | ==The crystal structure of the dimeric human importin alpha 1 at 2.5 angstrom resolution.== | ||
| - | <StructureSection load='4e4v' size='340' side='right' caption='[[4e4v]], [[Resolution|resolution]] 2.53Å' scene=''> | + | <StructureSection load='4e4v' size='340' side='right'caption='[[4e4v]], [[Resolution|resolution]] 2.53Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4e4v]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4e4v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E4V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E4V FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5283Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e4v OCA], [https://pdbe.org/4e4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e4v RCSB], [https://www.ebi.ac.uk/pdbsum/4e4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e4v ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/IMA1_HUMAN IMA1_HUMAN] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. |
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| + | ==See Also== | ||
| + | *[[Importin 3D structures|Importin 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Franke WA]] |
| - | [[Category: | + | [[Category: Hang PC]] |
| - | [[Category: | + | [[Category: Miknis ZM]] |
| - | [[Category: | + | [[Category: Schultz LW]] |
| - | [[Category: | + | [[Category: Umland TC]] |
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Current revision
The crystal structure of the dimeric human importin alpha 1 at 2.5 angstrom resolution.
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