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4ekd

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{{STRUCTURE_4ekd| PDB=4ekd | SCENE= }}
 
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===Structure of human regulator of G protein signaling 2 (RGS2) in complex with murine Galpha-q(R183C)===
 
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{{ABSTRACT_PUBMED_23434405}}
 
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==Function==
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==Structure of human regulator of G protein signaling 2 (RGS2) in complex with murine Galpha-q(R183C)==
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[[http://www.uniprot.org/uniprot/GNAQ_MOUSE GNAQ_MOUSE]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro).<ref>PMID:17938235</ref> <ref>PMID:20624888</ref> [[http://www.uniprot.org/uniprot/RGS2_HUMAN RGS2_HUMAN]] Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.<ref>PMID:11278586</ref> <ref>PMID:17901199</ref> <ref>PMID:7643615</ref> <ref>PMID:19736320</ref>
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<StructureSection load='4ekd' size='340' side='right'caption='[[4ekd]], [[Resolution|resolution]] 2.71&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ekd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EKD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EKD FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.71&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ekd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ekd OCA], [https://pdbe.org/4ekd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ekd RCSB], [https://www.ebi.ac.uk/pdbsum/4ekd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ekd ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RGS2_HUMAN RGS2_HUMAN] Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.<ref>PMID:11278586</ref> <ref>PMID:17901199</ref> <ref>PMID:7643615</ref> <ref>PMID:19736320</ref>
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==About this Structure==
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==See Also==
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[[4ekd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EKD OCA].
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*[[Regulator of G-protein signaling 3D structures|Regulator of G-protein signaling 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:023434405</ref><references group="xtra"/><references/>
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__TOC__
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[[Category: Heterotrimeric G-protein GTPase]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Nance, M R.]]
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[[Category: Nance MR]]
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[[Category: Tesmer, J J.G.]]
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[[Category: Tesmer JJG]]
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[[Category: Gtp-binding]]
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[[Category: Gtpase activation]]
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[[Category: Homology domain]]
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[[Category: Regulator of g protein signaling]]
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[[Category: Signaling protein-inhibitor complex]]
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Current revision

Structure of human regulator of G protein signaling 2 (RGS2) in complex with murine Galpha-q(R183C)

PDB ID 4ekd

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