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4exp
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of mouse Interleukin-34 in complex with mouse FMS== | |
| + | <StructureSection load='4exp' size='340' side='right'caption='[[4exp]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4exp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EXP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EXP FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4exp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4exp OCA], [https://pdbe.org/4exp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4exp RCSB], [https://www.ebi.ac.uk/pdbsum/4exp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4exp ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/IL34_MOUSE IL34_MOUSE] Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1 (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[Colony-stimulating factor receptor 3D structures|Colony-stimulating factor receptor 3D structures]] | |
| - | + | *[[Interleukin 3D structures|Interleukin 3D structures]] | |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Chen X]] | ||
| + | [[Category: He X]] | ||
| + | [[Category: Leo C]] | ||
| + | [[Category: Lin H]] | ||
| + | [[Category: Liu H]] | ||
| + | [[Category: Williams LT]] | ||
| + | [[Category: Wong BR]] | ||
Current revision
Structure of mouse Interleukin-34 in complex with mouse FMS
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Categories: Large Structures | Mus musculus | Chen X | He X | Leo C | Lin H | Liu H | Williams LT | Wong BR
