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4exp

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[[Image:4exp.jpg|left|200px]]
 
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==Structure of mouse Interleukin-34 in complex with mouse FMS==
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The line below this paragraph, containing "STRUCTURE_4exp", creates the "Structure Box" on the page.
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<StructureSection load='4exp' size='340' side='right'caption='[[4exp]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4exp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EXP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EXP FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_4exp| PDB=4exp | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4exp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4exp OCA], [https://pdbe.org/4exp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4exp RCSB], [https://www.ebi.ac.uk/pdbsum/4exp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4exp ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IL34_MOUSE IL34_MOUSE] Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1 (By similarity).
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===Structure of mouse Interleukin-34 in complex with mouse FMS===
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==See Also==
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*[[Colony-stimulating factor receptor 3D structures|Colony-stimulating factor receptor 3D structures]]
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*[[Interleukin 3D structures|Interleukin 3D structures]]
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__TOC__
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The line below this paragraph, {{ABSTRACT_PUBMED_22579672}}, adds the Publication Abstract to the page
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 22579672 is the PubMed ID number.
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_22579672}}
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==About this Structure==
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[[4exp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EXP OCA].
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==Reference==
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<ref group="xtra">PMID:022579672</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Receptor protein-tyrosine kinase]]
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[[Category: Chen X]]
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[[Category: Chen, X.]]
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[[Category: He X]]
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[[Category: He, X.]]
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[[Category: Leo C]]
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[[Category: Leo, C.]]
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[[Category: Lin H]]
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[[Category: Lin, H.]]
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[[Category: Liu H]]
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[[Category: Liu, H.]]
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[[Category: Williams LT]]
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[[Category: Williams, L T.]]
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[[Category: Wong BR]]
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[[Category: Wong, B R.]]
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[[Category: Beta-sandwich]]
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[[Category: Cytokine-transferase complex]]
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[[Category: Extended 4-helix bundle]]
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[[Category: Immunoglobunin]]
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Current revision

Structure of mouse Interleukin-34 in complex with mouse FMS

PDB ID 4exp

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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