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4f1y
From Proteopedia
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| - | [[Image:4f1y.jpg|left|200px]] | ||
| - | < | + | ==CNQX bound to the ligand binding domain of GluA3== |
| - | + | <StructureSection load='4f1y' size='340' side='right'caption='[[4f1y]], [[Resolution|resolution]] 1.79Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4f1y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F1Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F1Y FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.79Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CNI:7-NITRO-2,3-DIOXO-2,3-DIHYDROQUINOXALINE-6-CARBONITRILE'>CNI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f1y OCA], [https://pdbe.org/4f1y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f1y RCSB], [https://www.ebi.ac.uk/pdbsum/4f1y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f1y ProSAT]</span></td></tr> | |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GRIA3_RAT GRIA3_RAT] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity). | ||
| - | == | + | ==See Also== |
| - | + | *[[Glutamate receptor 3D structures|Glutamate receptor 3D structures]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | [[ | + | [[Category: Large Structures]] |
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
| - | [[Category: Ahmed | + | [[Category: Ahmed AH]] |
| - | [[Category: Oswald | + | [[Category: Oswald RE]] |
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Current revision
CNQX bound to the ligand binding domain of GluA3
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