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4f1y

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[[Image:4f1y.png|left|200px]]
 
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==CNQX bound to the ligand binding domain of GluA3==
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The line below this paragraph, containing "STRUCTURE_4f1y", creates the "Structure Box" on the page.
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<StructureSection load='4f1y' size='340' side='right'caption='[[4f1y]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4f1y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F1Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F1Y FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.79&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CNI:7-NITRO-2,3-DIOXO-2,3-DIHYDROQUINOXALINE-6-CARBONITRILE'>CNI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_4f1y| PDB=4f1y | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f1y OCA], [https://pdbe.org/4f1y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f1y RCSB], [https://www.ebi.ac.uk/pdbsum/4f1y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f1y ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GRIA3_RAT GRIA3_RAT] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity).
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===CNQX bound to the ligand binding domain of GluA3===
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==See Also==
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*[[Glutamate receptor 3D structures|Glutamate receptor 3D structures]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22512472 is the PubMed ID number.
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{{ABSTRACT_PUBMED_22512472}}
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==About this Structure==
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[[4f1y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F1Y OCA].
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==Reference==
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<ref group="xtra">PMID:022512472</ref><references group="xtra"/>
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Ahmed, A H.]]
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[[Category: Ahmed AH]]
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[[Category: Oswald, R E.]]
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[[Category: Oswald RE]]
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[[Category: Ampa receptor]]
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[[Category: Cnqx]]
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[[Category: Glua3]]
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[[Category: Glur3]]
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[[Category: Glutamate receptor]]
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[[Category: Lbd]]
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[[Category: Neurotransmitter receptor]]
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[[Category: S1s2]]
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[[Category: Transport protein]]
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[[Category: Transport protein-agonist complex]]
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Current revision

CNQX bound to the ligand binding domain of GluA3

PDB ID 4f1y

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